Document Detail

A New Sphingolipid and Furanocoumarins with Antimicrobial Activity from <i>Ficus exasperata</i>.
MedLine Citation:
PMID:  22863713     Owner:  NLM     Status:  In-Data-Review    
From the methanol extract of the stem bark of Ficus exasperata, a new sphingolipid named Ficusamide, (2S,3S,4R,11E)-2-[(2',3'-dihydroxyhexacosanoylamino)]-11-octadecene-1,3,4-triol (1), along with three known furanocoumarins, (S)-(-) oxypeucedanin hydrate (2), (R)-(+) oxypeucedanin hydrate (3), bergapten (5-methoxypsoralen) and six other known compounds, were isolated. Their structures were characterized basing on spectroscopic methods and chemical evidence. Compounds (1-3) were analyzed for their antimicrobial activity. Ficusamide (1) showed wick activity (minimal inhibitory concentration (MIC)=312.5 µg/mL) against Escherichia coli, while the furanocoumarins (2) and (3) showed significant activity (MIC=9.76 µg/mL) against Bacillus cereus, Candida albicans and Microsporum audouinii.
Marlise Diane Jiofack Dongfack; Marie-Christine Lallemand; Victor Kuete; Céline Djama Mbazoa; Jean-Duplex Wansi; Hanh Trinh-van-Dufat; Sylvie Michel; Jean Wandji
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  60     ISSN:  1347-5223     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1072-5     Citation Subset:  IM    
Laboratoire de Produits Naturels et de Synthèse des Hétérocycles, Département de Chimie Organique de l'Université de Yaoundé-1, Faculté des Sciences.
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