| New Sarcomatoid Cancer Cell Line SAR-HCV Established from a Hepatitis C Virus-related Liver Tumour Lesion. | |
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MedLine Citation:
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PMID: 21273590 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A sarcomatoid carcinoma cell line (SAR-HCV) was established from a malignant liver lesion of a patient infected with hepatitis C virus. SAR-HCV cells were successfully xenografted in SCID mice. Vimentin was strongly positive in cultured SAR-HCV cells, the primary tumour lesion and the xenografts. Hepatocyte paraffin 1 protein and certain cytokeratin markers, CK8, CK18 and AE1/AE3 were not detected in cultured cells, but were focally positive in the tumour lesion and xenografts, suggesting that this cancer cell line preserves some features of hepatocyte differentiation when grown in vivo. HLA class I, N-cadherin, vascular endothelial growth factor, CD44, and heat-shock protein 70 were moderately expressed in this cell line. Spectral karyotyping analysis revealed a nearly triploid karyotype, 34-63<3n>, XXY[12] with complicated genetic abnormalities of chromosomal structure in all metaphases examined. This cell line will be useful in further studying hepato-sarcomatoid carcinoma cells and in understanding carcinogenesis and epithelial-mesenchymal transition in hepatitis C virus-related liver tumour. |
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Authors:
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Dar-In Tai; Ya-Ju Shen; Wen-Hui Weng; Hui-Wen Chen; Chen-Chen Kang; Tse-Ching Chen; Shuen-Kuei Liao |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 31 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 129-37 Citation Subset: IM |
Affiliation:
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Cancer Immunotherapy Center, Cancer Center, Taipei Medical University Hospital, Taipei 110, Taiwan, R.O.C. liaosk@tmuh.org.tw. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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