Document Detail


New records in aerobic power among octogenarian lifelong endurance athletes.
MedLine Citation:
PMID:  23065759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined whole body aerobic capacity and myocellular markers of oxidative metabolism in lifelong endurance athletes [n = 9, 81 ± 1 yr, 68 ± 3 kg, body mass index (BMI) = 23 ± 1 kg/m(2)] and age-matched, healthy, untrained men (n = 6; 82 ± 1 y, 77 ± 5 kg, BMI = 26 ± 1 kg/m(2)). The endurance athletes were cross-country skiers, including a former Olympic champion and several national/regional champions, with a history of aerobic exercise and participation in endurance events throughout their lives. Each subject performed a maximal cycle test to assess aerobic capacity (VO(2max)). Subjects had a resting vastus lateralis muscle biopsy to assess oxidative enzymes (citrate synthase and βHAD) and molecular (mRNA) targets associated with mitochondrial biogenesis [peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) and mitochondrial transcription factor A (Tfam)]. The octogenarian athletes had a higher (P < 0.05) absolute (2.6 ± 0.1 vs. 1.6 ± 0.1 l/min) and relative (38 ± 1 vs. 21 ± 1 ml·kg(-1)·min(-1)) VO(2max), ventilation (79 ± 3 vs. 64 ± 7 l/min), heart rate (160 ± 5 vs. 146 ± 8 beats per minute), and final workload (182 ± 4 vs. 131 ± 14 W). Skeletal muscle oxidative enzymes were 54% (citrate synthase) and 42% (βHAD) higher (P < 0.05) in the octogenarian athletes. Likewise, basal PGC-1α and Tfam mRNA were 135% and 80% greater (P < 0.05) in the octogenarian athletes. To our knowledge, the VO(2max) of the lifelong endurance athletes is the highest recorded in humans >80 yr of age and comparable to nonendurance trained men 40 years younger. The superior cardiovascular and skeletal muscle health profile of the octogenarian athletes provides a large functional reserve above the aerobic frailty threshold and is associated with lower risk for disability and mortality.
Authors:
Scott Trappe; Erik Hayes; Andrew Galpin; Leonard Kaminsky; Bozena Jemiolo; William Fink; Todd Trappe; Anna Jansson; Thomas Gustafsson; Per Tesch
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-11
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  114     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-07-08     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-10     Citation Subset:  IM    
Export Citation:
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged, 80 and over
Athletes*
Body Composition / genetics,  physiology
Citrate (si)-Synthase / genetics,  metabolism
DNA-Binding Proteins / genetics,  metabolism
Exercise / physiology*
Heart Rate / genetics,  physiology
Heat-Shock Proteins / genetics,  metabolism
Humans
Male
Mitochondrial Proteins / genetics,  metabolism
Mitochondrial Turnover / genetics,  physiology
Muscle, Skeletal / enzymology,  metabolism,  physiology
Oxygen Consumption / genetics,  physiology
Physical Endurance / genetics,  physiology*
RNA, Messenger / genetics
Transcription Factors / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
AG038576/AG/NIA NIH HHS; R01 AG038576/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Heat-Shock Proteins; 0/Mitochondrial Proteins; 0/PPARGC1A protein, human; 0/RNA, Messenger; 0/TFAM protein, human; 0/Transcription Factors; EC 2.3.3.1/Citrate (si)-Synthase
Comments/Corrections
Comment In:
J Appl Physiol (1985). 2013 Jan 1;114(1):1-2   [PMID:  23139369 ]
J Appl Physiol (1985). 2013 Mar 15;114(6):830   [PMID:  23503695 ]
J Appl Physiol (1985). 2013 Mar 15;114(6):829   [PMID:  23503694 ]

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