| New Prognostic Markers for Outcome of Acute Pancreatitis: Overview of Reporting in 184 Studies. | |
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MedLine Citation:
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PMID: 21343832 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES:: The objective of this study was to assess the reporting of studies on new prognostic markers of outcome in acute pancreatitis. METHODS:: We used MEDLINE searches complemented with perusal of review articles' references to identify eligible English-language studies. We included studies evaluating nonroutine markers for acute pancreatitis. Eligible outcomes included Atlanta criteria, Japanese criteria for severity, multiple/single organ failure, complications, interventional treatment, hospitalization length, and death. We generated a 47-item checklist on Acute Pancreatitis Prognosis by adapting a previously constructed reporting guidance instrument for prognostic tumor markers (REMARK [Reporting Recommendations for Tumor Marker Prognostic Studies]). The checklist addresses the reporting of essential information in prognostic studies. RESULTS:: The 184 identified eligible studies reported on 196 different prognostic markers. One hundred forty-four studies (78.3%) found at least 1 prognostic marker to be nominally statistically significant. Significant improvements over time were seen in the reporting for 17 items, but major deficiencies were noted even in 2004-2009 studies. Particularly, 12 items were reported in less than 10% of studies overall and even within the most recent studies. CONCLUSIONS:: Despite some improvements over time, the reporting of important aspects of prognostic studies in acute pancreatitis remains suboptimal. The proposed REMARK-based checklist may help improve the quality and reporting of research in this field. |
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Authors:
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Dimitrios E Sigounas; Athina Tatsioni; Dimitrios K Christodoulou; Epameinondas V Tsianos; John P A Ioannidis |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-17 |
Journal Detail:
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Title: Pancreas Volume: - ISSN: 1536-4828 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *1st Department of Internal Medicine & Hepato-Gastroenterology Unit, and †Department of Internal Medicine, University of Ioannina School of Medicine, Ioannina, Greece; ‡Department of Medicine, Tufts University School of Medicine, and Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA; §Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine; ∥Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece; ¶Department of Epidemiology, Harvard School of Public Health, Boston, MA; and #Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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