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New Prognostic Markers for Outcome of Acute Pancreatitis: Overview of Reporting in 184 Studies.
MedLine Citation:
PMID:  21343832     Owner:  NLM     Status:  Publisher    
OBJECTIVES:: The objective of this study was to assess the reporting of studies on new prognostic markers of outcome in acute pancreatitis. METHODS:: We used MEDLINE searches complemented with perusal of review articles' references to identify eligible English-language studies. We included studies evaluating nonroutine markers for acute pancreatitis. Eligible outcomes included Atlanta criteria, Japanese criteria for severity, multiple/single organ failure, complications, interventional treatment, hospitalization length, and death. We generated a 47-item checklist on Acute Pancreatitis Prognosis by adapting a previously constructed reporting guidance instrument for prognostic tumor markers (REMARK [Reporting Recommendations for Tumor Marker Prognostic Studies]). The checklist addresses the reporting of essential information in prognostic studies. RESULTS:: The 184 identified eligible studies reported on 196 different prognostic markers. One hundred forty-four studies (78.3%) found at least 1 prognostic marker to be nominally statistically significant. Significant improvements over time were seen in the reporting for 17 items, but major deficiencies were noted even in 2004-2009 studies. Particularly, 12 items were reported in less than 10% of studies overall and even within the most recent studies. CONCLUSIONS:: Despite some improvements over time, the reporting of important aspects of prognostic studies in acute pancreatitis remains suboptimal. The proposed REMARK-based checklist may help improve the quality and reporting of research in this field.
Dimitrios E Sigounas; Athina Tatsioni; Dimitrios K Christodoulou; Epameinondas V Tsianos; John P A Ioannidis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-17
Journal Detail:
Title:  Pancreas     Volume:  -     ISSN:  1536-4828     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the *1st Department of Internal Medicine & Hepato-Gastroenterology Unit, and †Department of Internal Medicine, University of Ioannina School of Medicine, Ioannina, Greece; ‡Department of Medicine, Tufts University School of Medicine, and Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA; §Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine; ∥Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece; ¶Department of Epidemiology, Harvard School of Public Health, Boston, MA; and #Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA.
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