| New Photolabile BAPTA-based Ca2+ Cages with Improved Photorelease. | |
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MedLine Citation:
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PMID: 22519848 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The efficient synthesis, physicochemical and photolytical properties of a photoactivable BAPTA-based Ca2+ cage containing two photosensitive o-nitrobenzhydryl groups attached to the aromatic core are described. Ca2+ release in living cells was evaluated. The doubly substitution with the chromophores caused a significant improvement of the Ca2+ release properties of nitr-T against singly substituted reported nitr-x derivatives without compromising Ca2+/Mg2+ selectivity or pH insensitivity. Our results demonstrate a general strategy to improve light-triggered Ca2+ release which may open a door to prepare more efficient, selective and pH-insensitive photolabile Ca2+ chelators. |
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Authors:
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Jiaxi Cui; Radu A Gropeanu; David R Stevens; Jens Rettig; Aranzazu Del Campo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-22 |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: - ISSN: 1520-5126 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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