Document Detail


New Molecular and Cellular Targets for Chemoprevention and Treatment of Skin Tumours by Plant Polyphenols: A Critical Review.
MedLine Citation:
PMID:  23210776     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
As the incidence of skin tumours has been steadily growing, there is an urgent need for the preventive measures as well as in the improved therapeutic approaches. In the last two decades, natural plant derived polyphenols (PPs, resveratrol, silibinin, green tea polyphenols, flavonoids, anthocyanins, etc.) have been drawing particular interest as emerging active substances in dermatological/cosmeceutical compositions for the prevention, slowing, or reversion of skin tumorigenesis (chemoprevention). When chronically applied to the skin, they supposedly would not damage normal skin cells or negatively affect their functions while they would suppress tumorigenic cell transformation, inhibit tumour cell proliferation, and activate tumour cell apoptosis. PPs are also reported to synergize with conventional anti-cancer therapies. The major aim of this critical review is to provide recent updates on the molecular and cellular targets for the prevention and therapy of skin tumours with a special focus on the crossroad between inflammation and carcinogenesis as the most promising approach to chemoprevention. Novel therapeutic targets as different as epidermal stem cells, cellular senescence, epigenetic enzymes involved in carcinogenesis, epidermal growth factor and aryl hydrocarbon receptors, and metabolic CYP1 subfamily enzymes are highlighted. The mechanisms of PPs interaction with these molecular and cellular targets are reviewed. The feasibility of PPs to prevent/cure specific cutaneous toxicity connected to anti-EGFR therapy and to reduce multidrug resistance of skin tumours is also discussed.
Authors:
L G Korkina; S Pastore; E Dellambra; C De Luca
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-03
Journal Detail:
Title:  Current medicinal chemistry     Volume:  -     ISSN:  1875-533X     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Lab. Tissue Engineering & Skin Pathophysiology, Dermatology Institute (Istituto Dermopatico dell'Immacolata, IDI IRCCS), Rome 00167, Italy. l.korkina@idi.it.
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