| A new model for blunt liver injuries in the swine. | |
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MedLine Citation:
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PMID: 19996600 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To elaborate the impact of new haemostatic agents we developed an instrument for the pressure-controlled induction of blunt liver injuries in a porcine animal model. MATERIALS AND METHODS: A dilutional coagulopathy of 80% of animal blood volume was induced in 9 anaesthetized pigs. Animals were randomly assigned to be injured with a force of 112 Newton (N) (n = 1), 224 +/- 19 N (n = 4) or 355 +/- 35 N (n = 4). The impact of injury was measured by blood loss, survival time and coagulation parameters. Liver histology was obtained to evaluate the degree of liver injury. RESULTS: The profound haemodilution resulted in a significant alteration of all coagulation parameters. After inflicting the injury with 355 +/- 35 N, both the survival time (30 +/- 9 min; p = 0.006) and blood loss (68 +/- 16 ml min(-1), p = 0.002) were significantly different as compared to injuries with 224 +/- 19 N (survival time: 76 +/- 20 min, blood loss: 23 +/- 4 ml min(-1)). In contrast, an injury with 112 N led to an insignificant blood loss of only 239 ml. CONCLUSION: We developed a pressure-controlled clamp that allows for the induction of blunt liver traumas with highly reproducible injuries with a positive correlation with blood loss and survival. |
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Authors:
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O Grottke; T Braunschweig; B Philippen; K H Gatzweiler; N Gronloh; M Staat; R Rossaint; R Tolba |
Publication Detail:
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Type: Journal Article Date: 2009-12-09 |
Journal Detail:
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Title: European surgical research. Europ?ische chirurgische Forschung. Recherches chirurgicales europ?ennes Volume: 44 ISSN: 1421-9921 ISO Abbreviation: Eur Surg Res Publication Date: 2010 |
Date Detail:
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Created Date: 2010-02-26 Completed Date: 2010-05-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 65-73 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 S. Karger AG, Basel. |
Affiliation:
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Department of Anaesthesiology, Institute for Laboratory Animal Science, RWTH Aachen University Hospital, Pauwelsstrasse 30, Aachen, Germany. ogrottke@ukaachen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation Blood Pressure Blood Volume Cause of Death Disease Models, Animal Heart Rate Humans Liver / injuries* Male Models, Biological Platelet Count Shock, Hemorrhagic / mortality Swine Wounds, Nonpenetrating / blood, pathology, veterinary* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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