Document Detail

A New Mild Method for the C-Acylation of Ketone Enolates. A Convenient Synthesis of β-Keto-Esters, -Thionoesters, and -Thioesters.
MedLine Citation:
PMID:  23276289     Owner:  NLM     Status:  Publisher    
A new method for ketone enolate C-acylation is described which utilizes alkyl pentafluorophenylcarbonates, thiocarbonates, and thionocarbonates as the reactive acylating agents, and MgBr(2)·Et(2)O, DMAP, and i-Pr(2)NEt as the reagents for enolization. A wide range of ketones have been observed to undergo clean C-acylation via this protocol.
Karl J Hale; Milosz Grabski; Jakub T Flasz
Related Documents :
23075119 - One-pot synthesis of 1-iodoalkynes and trisubstituted alkenes from benzylic and allylic...
21367079 - 93 effect of antioxidants supplementation on the quality of cryopreserved sperm of dogs.
22938519 - Straightforward synthesis of dihydrobenzo[a]fluorenes through au(i)-catalyzed formal [3...
11563029 - Preparation of 3'-c-branched uridine analogues, suitable for conversion into functional...
21565729 - Effect of europium(ii) stearate on the mechanical properties and the oxidation resistan...
24734059 - Synthesis of brominated 2-phenitidine derivatives as valuable inhibitors of cholinester...
20101929 - A case of anaphylaxis: horse-fly or hymenoptera sting?
25315639 - Optimized preparation of a (99m)tc-radiolabeled probe for tracing microrna.
19480409 - Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazo...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-31
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
The School of Chemistry and Chemical Engineering, and the CCRCB, Queen's University Belfast , Stranmillis Road, Belfast BT9 5AG, Northern Ireland, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications fo...
Next Document:  Development and Validation of a Multilateral Index to Determine Economic Status in Developing Countr...