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A New Method for Evaluation of Motor Injury after Acute Brain Ischemic Damage.
MedLine Citation:
PMID:  24901953     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Purpose: Motor impairment is an important index for assessing the extent of brain injury. The present study uses a new method, the movement capture analysis (MOCA) system, for assessing motor damage after acute ischemia. Materials and Methods: Forty rats were divided into four groups: standard ischemia, sham-operated, Dizocilpine (MK-801) and Ginkgo biloba extract (GBE) groups. Brain ischemia was induced using the temporary right middle cerebral artery occlusion model. Longa score and MOCA were used to assess motor injury one day after ischemia. Infarct volume was delineated with 2% 2,3,5-triphenyltetrazolium chloride (TTC) staining. The correlation of infarct volume with Longa score and MOCA data was calculated. Results: Compared with the sham-operated group (0.10 ± 0.31), Longa scores of MK-801 (2.33 ± 0.73), GBE (1.80 ±0.58) and standard (2.88 ± 0.83) groups showed a statistical difference (P<0.05); however, it was unable to discern the difference between MK-801 and standard groups. MOCA was able to clearly discern the differences in motor disparity among the four groups, standard (1.00 ± 0.19), sham-operated group (0.17 ± 0.02), MK-801 (0.79 ± 0.08), GBE (0.38 ± 0.05) (P<0.05). Both MK-801 (18.03 ± 0.96%) and GBE (10.82 ± 1.93%) treatment reduced infarct size compared with the standard ischemia group (25.88 ± 1.16%) (P<0.05). The MOCA data showed a more significant correlation with infarct size than Longa score (r = 0.85:0.53). Conclusions: MOCA system proved to be more sensitive than the Longa score. It may potentially be more accurate method for behavioral evaluation in clinical trials.
Authors:
Zeng-Chun Hu; Hui Ma; Qing Fan; Jian Yin; Ming-Hai Wei; Yong-Zhong Lin; Ming Fan; Chang-Kai Sun
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-5
Journal Detail:
Title:  The International journal of neuroscience     Volume:  -     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-31     Citation Subset:  -    
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