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A New Method for Cardiac Computed Tomography Regional Function Assessment: Stretch Quantifier for Endocardial Engraved Zones (SQUEEZ).
MedLine Citation:
PMID:  22342945     Owner:  NLM     Status:  Publisher    
BACKGROUND: -Quantitative assessment of regional myocardial function has important diagnostic implications in cardiac disease. Recent advances in computed tomography (CT) imaging technology allow fine anatomical structures such as endocardial trabeculae to be resolved and potentially used as fiducial markers for tracking local wall deformations. We developed a method to detect and track such features on the endocardium to extract a measure that reflects local myocardial contraction. METHODS AND RESULTS: -First-pass CT images and contrast enhanced CMR images were acquired for a total of 11 infarcted (n=8) and healthy (n=3) pigs. We tracked the left ventricle wall motion by segmenting the blood from myocardium and calculating trajectories of the endocardial features seen on the "blood-cast". The relative motions of these surface features were used to represent the local contraction of the endocardial surface with a metric we termed "stretch quantifier of endocardial engraved zones" (SQUEEZ). The average SQUEEZ value and the rate of change in SQUEEZ were calculated for both infarcted and healthy myocardial regions. SQUEEZ showed significant difference between infarct and remote regions (p<0.0001). No significant difference was observed between normal myocardium (non-infarcted hearts) and remote regions (p=0.8). CONCLUSIONS: -We present a new quantitative method for measuring regional cardiac function from high resolution volumetric CT images which can be acquired during angiography and myocardial perfusion scans. Quantified measures of regional cardiac mechanics in normal and abnormally contracting regions in infarcted hearts were shown to correspond well with non-infarcted and infarcted regions as detected by delayed enhanced CMR images.
Amir Pourmorteza; Karl H Schuleri; Daniel A Herzka; Albert C Lardo; Elliot R McVeigh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-16
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  -     ISSN:  1942-0080     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Johns Hopkins University School of Medicine, Baltimore, MD.
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