| New Mechanisms of Pulmonary Arterial Hypertension: Role of Ca2+ Signaling. | |
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MedLine Citation:
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PMID: 22245772 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Pulmonary arterial hypertension (PAH) is a severe and progressive disease that usually culminates in right heart failure and death if left untreated. Although there have been substantial improvements in our understanding and significant advances in the management of this disease, there is a grim prognosis for patients in the advanced stages of PAH. A major cause of PAH is increased pulmonary vascular resistance (PVR) which results from sustained vasoconstriction, excessive pulmonary vascular remodeling, in situ thrombosis, and increased pulmonary vascular stiffness. In addition to other signal transduction pathways, Ca(2+) signaling in pulmonary artery smooth muscle cells (PASMC) plays a central role in the development and progression of PAH due to its involvement in both vasoconstriction through its pivotal effect of PASMC contraction, and vascular remodeling through its stimulatory effect on PASMC proliferation. Altered expression, function and regulation of ion channels and transporters in PASMC contribute to an increased cytosolic Ca(2+) concentration ([Ca(2+)](cyt)) and enhanced Ca(2+) signaling in patients with PAH. This review will focus on the potential pathogenic role of Ca(2+) mobilization, regulation and signaling in the development and progression of PAH. |
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Authors:
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Frank K Kuhr; Kimberly A Smith; Michael Y Song; Irena Levitan; Jason X-J Yuan |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Illinois at Chicago. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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