| New MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantification. | |
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MedLine Citation:
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PMID: 19422919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normalization of neuroimaging studies to a stereotaxic space allows the utilization of standard volumes of interest (VOIs) and voxel-based analysis (SPM). Such spatial normalization of PET and MRI studies requires a high quality template image. The aim of this study was to create new MRI and PET templates of (18)F-DOPA and (11)C-(+)-alpha-dihydrotetrabenazine ((11)C-DTBZ) of the Macaca fascicularis brain, an important animal model of Parkinson's disease. MRI template was constructed as a smoothed average of the scans of 15 healthy animals, previously transformed into the space of one representative MRI. In order to create the PET templates, (18)F-DOPA and (11)C-DTBZ PET of the same subjects were acquired in a dedicated small animal PET scanner and transformed to the created MRI template space. To validate these templates for PET quantification, parametric values obtained with a standard VOI-map applied after spatial normalization to each template were statistically compared to results computed using individual VOIs drawn for each animal. The high correlation between both procedures validated the utilization of all the templates, improving the reproducibility of PET analysis. To prove the utility of the templates for voxel-based quantification, dopamine striatal depletion in a representative monkey treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was assessed by SPM analysis of (11)C-DTBZ PET. A symmetric reduction in striatal (11)C-DTBZ uptake was detected in accordance with the induced lesion. In conclusion, templates of M. fascicularis brain have been constructed and validated for reproducible and automated PET quantification. All templates are electronically available via the internet. |
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Authors:
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M Collantes; E Prieto; I Peñuelas; J Blesa; C Juri; J M Martí-Climent; G Quincoces; J Arbizu; M Riverol; J L Zubieta; M C Rodriguez-Oroz; M R Luquin; J A Richter; J A Obeso |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2009-05-05 |
Journal Detail:
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Title: NeuroImage Volume: 47 ISSN: 1095-9572 ISO Abbreviation: Neuroimage Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 533-9 Citation Subset: IM |
Affiliation:
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Small Animal Imaging Research Unit, Center for Applied Medical Research (CIMA) and Clínica Universidad de Navarra, Pamplona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / anatomy & histology*, radionuclide imaging* Carbon Radioisotopes / diagnostic use Dihydroxyphenylalanine / analogs & derivatives*, diagnostic use Image Enhancement / methods* Macaca fascicularis Magnetic Resonance Imaging / methods* Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Reference Values Subtraction Technique Tetrabenazine / analogs & derivatives*, diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Radiopharmaceuticals; 3466-75-9/dihydrotetrabenazine; 58-46-8/Tetrabenazine; 63-84-3/Dihydroxyphenylalanine; 75290-51-6/fluorodopa F 18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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