Document Detail

New Intracanal Formulations Containing Doxycycline or Chlorhexidine Against Enterococcus faecalis.
MedLine Citation:
PMID:  24939266     Owner:  NLM     Status:  Publisher    
The present study aims to evaluate the antimicrobial effect of two new intracanal preparations against E. faecalis. Thirty single-rooted human canine teeth were used. The crowns were removed and the roots were instrumented using a conventional technique. Three groups of ten teeth each were infected with 108 CFU/ ml of E. faecalis for 21 days. The root canals were flled with new intracanal medications containing 3% doxycycline hydrochloride (DX) or 2% chlorhexidine digluconate (CHX). Ten teeth received no medication (NM)-negative control. Microbial samples were obtained 21 days after contamination: 14 days under the effect of the intracanal medications and 7 days after replacing the medications by BHI broth. The samples were homogenized, diluted, seeded on BHI agar and incubated for 48h/36°C. The number of colony forming units (CFU/ml) was obtained and analyzed statistically. All intracanal dressings signifcantly reduced the number of bacterial cells in the root canal after 14 days with medication. After the period with 7 days with BHI broth, the CFU counts of E. faecalis remained at low values. However, the NM group showed a signifcant increase of CFU in this period to similar values of the initial contamination. 3% doxycycline hydrochloride gel and 2% CHX gel were effective to eliminate E. faecalis from the root canal system. Keywords: Endodontics, Enterococcus faecalis, Doxycycline, Chlorhexidine. How to cite this article: da Silva ARM, Pinto SCS, dos Santos EB, dos Santos FA, Farago PV, Gomes JC, Pina-Vaz I, Carvalho MF. New Intracanal Formulations Containing Doxycycline or Chlorhexidine Against Enterococcus faecalis. J Contemp Dent Pract 2014;15(1):61-65. Source of support: Nil Confict of interest: None declared.
Ana Rita Marques da Silva; Shelon Cristina Souza; Elizabete Brasil Dos Santos; Fábio André Dos Santos; Paulo Vitor Farago; João Carlos Gomes; Irene Pina-Vaz; Manuel Fontes Carvalho
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-1
Journal Detail:
Title:  The journal of contemporary dental practice     Volume:  15     ISSN:  1526-3711     ISO Abbreviation:  J Contemp Dent Pract     Publication Date:  2014  
Date Detail:
Created Date:  2014-6-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101090552     Medline TA:  J Contemp Dent Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  61-65     Citation Subset:  -    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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