Document Detail

New insights into the shikimate and aromatic amino acids biosynthesis pathways in plants.
MedLine Citation:
PMID:  20817774     Owner:  NLM     Status:  In-Process    
The aromatic amino acids phenylalanine, tyrosine, and tryptophan in plants are not only essential components of protein synthesis, but also serve as precursors for a wide range of secondary metabolites that are important for plant growth as well as for human nutrition and health. The aromatic amino acids are synthesized via the shikimate pathway followed by the branched aromatic amino acids biosynthesis pathway, with chorismate serving as a major intermediate branch point metabolite. Yet, the regulation and coordination of synthesis of these amino acids are still far from being understood. Recent studies on these pathways identified a number of alternative cross-regulated biosynthesis routes with unique evolutionary origins. Although the major route of Phe and Tyr biosynthesis in plants occurs via the intermediate metabolite arogenate, recent studies suggest that plants can also synthesize phenylalanine via the intermediate metabolite phenylpyruvate (PPY), similarly to many microorganisms. Recent studies also identified a number of transcription factors regulating the expression of genes encoding enzymes of the shikimate and aromatic amino acids pathways as well as of multiple secondary metabolites derived from them in Arabidopsis and in other plant species.
Vered Tzin; Gad Galili
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-03
Journal Detail:
Title:  Molecular plant     Volume:  3     ISSN:  1752-9867     ISO Abbreviation:  Mol Plant     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101465514     Medline TA:  Mol Plant     Country:  England    
Other Details:
Languages:  eng     Pagination:  956-72     Citation Subset:  IM    
Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.
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