Document Detail


New Insights into the Role of Chronic Inflammation and Cytokines in Etiopathogenesis of GEP-NETs.
MedLine Citation:
PMID:  24686050     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although previously considered rare, recent epidemiological studies have revealed that the incidence (3.6/100,000) and prevalence (35/100,000) of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) has increased over the past few decades. Despite the progress in the understanding of GEP-NETs molecular biology, there is still little advance in the early diagnosis due to lack of specific tumour markers. As the tumours are mostly detected in their late stage, they are not well controlled by either biotherapy or conventional chemotherapy, and thus represent a significant clinical issue. Chronic inflammation has been implicated in the development of GEP-NETs. This review presents recent findings that link pro-inflammatory cytokines to molecular basis of GEP-NETs tumorigenesis, leading to a more personalized approach to disease management and therapy. © 2014 S. Karger AG, Basel.
Authors:
Maja Cigrovski Berkovic; Tamara Cacev; Tina Catela Ivkovic; Vanja Zjacic-Rotkvic; Sanja Kapitanovic
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-28
Journal Detail:
Title:  Neuroendocrinology     Volume:  -     ISSN:  1423-0194     ISO Abbreviation:  Neuroendocrinology     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-4-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0035665     Medline TA:  Neuroendocrinology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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