Document Detail

New insights into mechanisms of stem cell daughter fate determination in regenerative tissues.
MedLine Citation:
PMID:  23273858     Owner:  NLM     Status:  MEDLINE    
Stem cells can self-renew and differentiate over extended periods of time. Understanding how stem cells acquire their fates is a central question in stem cell biology. Early work in Drosophila germ line and neuroblast showed that fate choice is achieved by strict asymmetric divisions that can generate each time one stem and one differentiated cell. More recent work suggests that during homeostasis, some stem cells can divide symmetrically to generate two differentiated cells or two identical stem cells to compensate for stem cell loss that occurred by direct differentiation or apoptosis. The interplay of all these factors ensures constant tissue regeneration and the maintenance of stem cell pool size. This interplay can be modeled as a population-deterministic dynamics that, at least in some systems, may be described as stochastic behavior. Here, we overview recent progress made on the characterization of stem cell dynamics in regenerative tissues.
Aiko Sada; Tudorita Tumbar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International review of cell and molecular biology     Volume:  300     ISSN:  1937-6448     ISO Abbreviation:  Int Rev Cell Mol Biol     Publication Date:  2013  
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-06-06     Revised Date:  2013-07-26    
Medline Journal Info:
Nlm Unique ID:  101475846     Medline TA:  Int Rev Cell Mol Biol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
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MeSH Terms
Caenorhabditis elegans
Cell Differentiation / physiology
Cell Division / physiology
Models, Biological
Regeneration / physiology*
Stem Cell Niche / physiology
Stem Cells / cytology*,  physiology*
Grant Support

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