Document Detail

New H2-receptor antagonist--roxatidine acetate--in treatment of duodenal ulcer.
MedLine Citation:
PMID:  7904993     Owner:  NLM     Status:  MEDLINE    
A double blind randomised trial, comparing a new H2-receptor antagonist, Roxatidine acetate, with Cimetidine was carried out in 47 patients of uncomplicated, endoscopically proven duodenal ulcer. Twenty seven patients were treated with Roxatidine 75 mg twice daily and 20 patients were treated with Cimetidine 200 mg 3 times a day and 400 mg at bed time for 4 weeks. At the end of 4 weeks, total pain relief was obtained in 74% and 70% patients receiving Roxatidine and Cimetidine respectively. Complete endoscopic healing at the end of 4 weeks was observed in 92.3% patients receiving Roxatidine and 85% patients receiving Cimetidine. These differences were statistically not significant. No significant side effects were observed in either group. We conclude that Roxatidine acetate is comparable to cimetidine in relieving pain and endoscopic healing of duodenal ulcer and has an excellent safety profile.
D N Amarapurkar; S S Parikh; H G Desai
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  41     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1994-03-03     Completed Date:  1994-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  496-7     Citation Subset:  IM    
BYL Nair Charitable Hospital, Bombay.
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MeSH Terms
Cimetidine / therapeutic use
Double-Blind Method
Duodenal Ulcer / drug therapy*
Histamine H2 Antagonists / therapeutic use*
Piperidines / therapeutic use*
Reg. No./Substance:
0/Histamine H2 Antagonists; 0/Piperidines; 51481-61-9/Cimetidine; 78628-28-1/roxatidine acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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