| A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures. | |
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MedLine Citation:
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PMID: 21615126 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A new machine for conducting continuous flow processes at low temperatures on a laboratory scale is reported. The use of this cryogenic flow reactor has been demonstrated by the preparation of a variety of (hetero)aromatic boronic acids and esters via lithium halogen exchange chemistry. Furthermore, scale-up of the reaction conditions not only demonstrates the application of this device for the preparation of useful building blocks but also combines the ability to process n-butyllithium directly through pump heads attached to the unit. |
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Authors:
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Duncan L Browne; Marcus Baumann; Bashir H Harji; Ian R Baxendale; Steven V Ley |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-26 |
Journal Detail:
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Title: Organic letters Volume: - ISSN: 1523-7052 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K., and Cambridge Reactor Design, Unit D2 Brookfield Business Centre, Cottenham, CB24 8PS, U.K. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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