Document Detail

A new dietary inflammatory index predicts interval changes in serum high-sensitivity C-reactive protein.
MedLine Citation:
PMID:  19864399     Owner:  NLM     Status:  MEDLINE    
Inflammation is associated with a number of chronic conditions, such as cancer and cardiovascular disease. Reducing inflammation may help prevent or treat these conditions. Diet has consistently been shown to modulate inflammation. To facilitate research into the inflammatory effect of diet on health in humans, we sought to develop and validate an Inflammatory Index designed to assess the inflammatory potential of individuals' diets. An Inflammatory Index was developed based on the results of an extensive literature search. Using data from a longitudinal observational study that carefully measured diet and the inflammatory marker, serum high-sensitivity (hs) C-reactive protein (CRP), in approximately 600 adults for 1 y, we conducted analyses to test the effect of Inflammatory Index score on hs-CRP as a continuous and dichotomous (<or=3 mg/L, >3 mg/L) indicator of inflammatory response, while controlling for important potential confounders. Results based on continuous measures of hs-CRP suggested that an increasing Inflammatory Index score (representing movement toward an antiinflammatory diet) was associated with a decrease in hs-CRP. Analyses using hs-CRP as a dichotomous variable showed that an antiinflammatory diet was associated with a decrease in the odds of an elevated hs-CRP (P = 0.049). The results are consistent with the ability of the Inflammatory Index to predict hs-CRP and provide additional evidence that diet plays a role in the regulation of inflammation, even after careful control of a wide variety of potential confounders.
Philip P Cavicchia; Susan E Steck; Thomas G Hurley; James R Hussey; Yunsheng Ma; Ira S Ockene; James R Hébert
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-10-28
Journal Detail:
Title:  The Journal of nutrition     Volume:  139     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-01-06     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2365-72     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / analysis,  metabolism*
Diet / adverse effects*
Energy Intake
Inflammation / blood,  diagnosis*,  prevention & control
Interleukin-1 / blood
Interleukin-10 / blood
Interleukin-4 / blood
Interleukin-6 / blood
Interviews as Topic
Middle Aged
Reference Values
Search Engine
Sensitivity and Specificity
Tumor Necrosis Factor-alpha / blood
Grant Support
1R01 HL073194-01/HL/NHLBI NIH HHS; K05 CA136975/CA/NCI NIH HHS; K05 CA136975/CA/NCI NIH HHS; K05 CA136975-03/CA/NCI NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-1; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 207137-56-2/Interleukin-4; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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