Document Detail


New Design of Thiol-Responsive Degradable Polylactide-Based Block Copolymer Micelles.
MedLine Citation:
PMID:  23019134     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A new design to synthesize thiol-responsive degradable polylactide (PLA)-based micelles having a disulfide linkage in the middle of triblock copolymers is reported. They were synthesized by a new method that centers on the use of a disulfide-labeled diol as an initiator for ring-opening polymerization, followed by controlled radical polymerization. These well-controlled copolymers with monomodal and narrow molecular weight distribution (M(w) /M(n) < 1.15) self-assembled to form aqueous micellar aggregates with disulfide-containing PLA cores, which is not toxic to cells. Central disulfide linkages were cleaved in response to thiols; such thiol-triggered degradation enhanced the release of encapsulated anticancer drugs.
Authors:
Alexander Cunningham; Jung Kwon Oh
Related Documents :
23779154 - The enhanced effect of surface microstructured porous titanium on adhesion and osteobla...
3557894 - Dissolution of gallstones using cholecystostomy tube in the pig.
24115434 - Evidence for water in the rocky debris of a disrupted extrasolar minor planet.
24121784 - Transient evoked otoacoustic emissions and vestibular evoked myogenic potentials in cig...
12809534 - Surface area of respirable beryllium metal, oxide, and copper alloy aerosols and implic...
23307784 - Azobenzene photoswitches for staudinger-bertozzi ligation.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Macromolecular rapid communications     Volume:  -     ISSN:  1521-3927     ISO Abbreviation:  Macromol Rapid Commun     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9888239     Medline TA:  Macromol Rapid Commun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Chemistry and Biochemistry and Centre for Nanoscience Research (CENR), Concordia University, Montreal, Quebec, Canada H4B 1R6.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Determination of musk fragrances in sewage sludge by pressurized liquid extraction coupled to automa...
Next Document:  Mouse models of growth hormone action and aging: a proteomic perspective.