Document Detail


A New Concept in Treatment of Burn Injury: Controlled Slow-Release Granulocyte-Monocyte Colony-Stimulating Factor Chitosan Gel System.
MedLine Citation:
PMID:  22123539     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE:: The aim of the study is to investigate the effectiveness of the controlled slow-release granulocyte-monocyte colony-stimulating factor (GM-CSF) system in burn wound healing. MATERIAL AND METHODS:: In vivo effect of controlled slow-release GM-CSF from chitosan gel on burn wound healing was evaluated on 18 Wistar-Albino rats, weighing between 250 and 300 g. They were randomly divided into 3 groups; (1) burned only group (n = 6), (2) burned + chitosan group (n = 6), (3) burned + chitosan + GM-CSF group (n = 6). Wound area was measured macroscopically. Hematoxylin and eosin and Masson's trichrome stained sections were evaluated for wound healing and tissue response to the polymer. RESULTS:: The best healing process was observed with the controlled slow-release GM-CSF-applied group (group 3) in which the wound area was significantly narrowed. CONCLUSION:: The study demonstrated the positive contribution of the single-dose controlled slow-release GM-CSF from chitosan gel on burn wound healing.
Authors:
Serife Simsek; Halil Ibrahim Canter; Ersoy Konas; Petek Korkusuz; Devrim Demir; Filiz Oner; Ibrahim Unsal; Mehmet Emin Mavili
Related Documents :
19549209 - Endoscopic classification for reflux pharyngolaryngitis.
18625129 - Endoscopic therapy for gerd: does it have a future?
3954499 - Corrosive burns of the esophagus and stomach: a recommendation for an aggressive surgic...
16675239 - Long-term results after heller-dor operation for oesophageal achalasia.
15711819 - Nissen or partial posterior fundoplication: which antireflux procedure has a lower rate...
3707229 - Achalasia of the esophagus. treatment controversies and the method of choice.
22890119 - A perioperative smoking cessation intervention with varenicline: a double-blind, random...
9527749 - Cardiovascular effects of two different regional anaesthetic techniques for unilateral ...
23839209 - The self-aligning knee prosthesis: clinical and radiological outcome and survival analy...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  67     ISSN:  1536-3708     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  583-588     Citation Subset:  -    
Affiliation:
From the *Acibadem Health Group, Department of General Surgery, Atasehir Hospital, Istanbul, Turkey; †Department of Plastic and Reconstructive Surgery, Acibadem University, Istanbul, Turkey; ‡Department of Plastic and Reconstructive Surgery, Hacettepe University, Ankara, Turkey; §Department of Histology and Embryology, Hacettepe University, Ankara, Turkey; ¶Department of Pharmaceutical Biotechnology, Ege University, Izmir, Turkey; ‖Department of Pharmaceutical Biotechnology, Hacettepe University, Ankara, Turkey; and **Department of Biochemistry, Acibadem University Faculty of Medicine, Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prevalence and work-related risk factors for reduced activities and absenteeism due to low back symp...
Next Document:  Study of sensory and motor fascicles in brachial plexus and establishment of a digital three-dimensi...