Document Detail

A New Concept in Treatment of Burn Injury: Controlled Slow-Release Granulocyte-Monocyte Colony-Stimulating Factor Chitosan Gel System.
MedLine Citation:
PMID:  22123539     Owner:  NLM     Status:  Publisher    
OBJECTIVE:: The aim of the study is to investigate the effectiveness of the controlled slow-release granulocyte-monocyte colony-stimulating factor (GM-CSF) system in burn wound healing. MATERIAL AND METHODS:: In vivo effect of controlled slow-release GM-CSF from chitosan gel on burn wound healing was evaluated on 18 Wistar-Albino rats, weighing between 250 and 300 g. They were randomly divided into 3 groups; (1) burned only group (n = 6), (2) burned + chitosan group (n = 6), (3) burned + chitosan + GM-CSF group (n = 6). Wound area was measured macroscopically. Hematoxylin and eosin and Masson's trichrome stained sections were evaluated for wound healing and tissue response to the polymer. RESULTS:: The best healing process was observed with the controlled slow-release GM-CSF-applied group (group 3) in which the wound area was significantly narrowed. CONCLUSION:: The study demonstrated the positive contribution of the single-dose controlled slow-release GM-CSF from chitosan gel on burn wound healing.
Serife Simsek; Halil Ibrahim Canter; Ersoy Konas; Petek Korkusuz; Devrim Demir; Filiz Oner; Ibrahim Unsal; Mehmet Emin Mavili
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Publication Detail:
Journal Detail:
Title:  Annals of plastic surgery     Volume:  67     ISSN:  1536-3708     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  583-588     Citation Subset:  -    
From the *Acibadem Health Group, Department of General Surgery, Atasehir Hospital, Istanbul, Turkey; †Department of Plastic and Reconstructive Surgery, Acibadem University, Istanbul, Turkey; ‡Department of Plastic and Reconstructive Surgery, Hacettepe University, Ankara, Turkey; §Department of Histology and Embryology, Hacettepe University, Ankara, Turkey; ¶Department of Pharmaceutical Biotechnology, Ege University, Izmir, Turkey; ‖Department of Pharmaceutical Biotechnology, Hacettepe University, Ankara, Turkey; and **Department of Biochemistry, Acibadem University Faculty of Medicine, Istanbul, Turkey.
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