Document Detail

A New Catalyst for the Asymmetric Henry Reaction: Synthesis of β-Nitroethanols in High Enantiomeric Excess.
MedLine Citation:
PMID:  23194499     Owner:  NLM     Status:  Publisher    
A new chiral tetrahydrosalen ligand has been designed and synthesized from cis-2,5-diaminobicyclo[2.2.2]octane. The complex generated in situ by the interaction of the ligand with (CuOTf)(2)·C(6)H(5)CH(3) was an efficient catalyst for the asymmetric Henry reaction, producing nitroaldol products in high yield and good stereoselectivity. Henry reactions catalyzed by this tetrahydrosalen-Cu(I) complex led to syntheses of β-adrenergic blocking agents (S)-toliprolol, (S)-moprolol, and (S)-propanolol.
James D White; Subrata Shaw
Related Documents :
8582029 - Novel potassium channel activators: synthesis and structure-activity relationship studi...
24960109 - Efficient assembly of polysubstituted pyrroles via a (3 + 2) cycloaddition/skeletal rea...
23019449 - Photoreactions of cyclic sulfite esters: evidence for diradical intermediates.
24517589 - Mild synthesis of chalcones via rhodium(iii)-catalyzed c-c coupling of arenes and cyclo...
24485989 - (232)th(d,4n)(230)pa cross-section measurements at arronax facility for the production ...
23925529 - Enhanced gellan gum production by hydrogen peroxide (h2o 2) induced oxidative stresses ...
15471469 - Asymmetric hetero-diels-alder reactions of n-sulfinyl dienophiles using chiral bis(oxaz...
25446849 - Spectroscopic studies on the in vitro antioxidant capacity of isopentyl ferulate.
22616579 - Total synthesis and biological evaluation of transvalencin z.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-30
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Chemistry, Oregon State University , Corvallis, Oregon 97331, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cardiovascular risk assessment: addition of CKD and race to the Framingham equation.
Next Document:  Rapid and sensitive identification of RNA from the emerging pathogen, coxsackievirus A6.