Document Detail


A new canine carotid artery bifurcation aneurysm model for the evaluation of neurovascular devices.
MedLine Citation:
PMID:  20019111     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Stents are increasingly used for coiling of difficult aneurysms, to reduce the risk of recurrences, or to modify blood flow. Currently available bifurcation aneurysm models are ill-suited to assess stent performance before clinical use. We designed a new wide-neck canine T-type bifurcation aneurysm model. Its potential value as a training tool as well as in the evaluation of new techniques or embolic agents was assessed. Our first task was to verify that recurrences occurred after satisfactory coiling. A second aim of this preliminary work was to assess if the new model could recreate the technical challenges involved in bifurcation aneurysms. MATERIALS AND METHODS: We introduce a new canine wide-neck bifurcation aneurysm model, created by using a vein pouch at the apex of an end-to-side anastomosis of the carotid arteries, with flow reversal in the proximal RCA by ligation of the innominate artery. Three aneurysms were treated with coil embolization, 10 were treated with stents (7 self-expandable, 3 balloon-expandable), and 3 were left untreated. Aneurysms were followed by duplex ultrasonography and angiography, and studied with macroscopic photography after euthanasia 11.8 +/- 3.9 months after surgery. RESULTS: All aneurysms remained patent at 9.0 +/- 3.6 months' follow-up. Coiling led to recurrences by 3 months in all 3 cases. Stent placement was technically difficult in all cases and did not lead to aneurysm thrombosis or neointimal closure of the aneurysm neck at 3 months. CONCLUSIONS: This model may be suitable for studying the effects of endovascular treatment on aneurysm and branch occlusion rates, for preclinical testing of stents and other intravascular devices, and for training students of endovascular technique.
Authors:
O Naggara; T E Darsaut; I Salazkin; G Soulez; F Guilbert; D Roy; A Weill; G Gevry; J Raymond
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-17
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  31     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  967-71     Citation Subset:  IM    
Affiliation:
Interventional Neuroradiology Research Unit, Department of Radiology, Centre Hospitalier de l'Université de Montréal, Notre-Dame Hospital, Montreal, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Vessel Prosthesis*
Carotid Artery Diseases / diagnosis*,  surgery*
Disease Models, Animal*
Dogs
Humans
Intracranial Aneurysm / diagnosis*,  surgery*
Stents*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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