Document Detail

A New Bilayer Chitosan Scaffolding as a Dural Substitute: Experimental Evaluation.
MedLine Citation:
PMID:  22120335     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To evaluate whether bilayer chitosan scaffolding (BChS) can provide a watertight dural closure and permit regeneration by fibroblasts in an experimental in vivo model. METHODS: In the in vitro phase, BChS was elaborated and the following characteristics were evaluated: pore size, thickness, water absorption capacity, tensile strength, strain, and toughness. In the second in vivo phase, 27 durectomized New Zealand rabbits were randomly assigned into three duraplasty groups with autologous dura, collagen matrix (CM), or BChS. In all groups, fluid leakage pressure was measured at 10, 21, or 180 days. Histology response to regeneration was evaluated through hematoxylin and eosin stain. RESULTS: BChS was standardized to obtain bilayer scaffoldings with a nonporous layer and a porous layer. The pore size was 10 μm, total thickness was 400 μm, strain was 57.8%, and tensile strength was 5.5 gr/mm(2). The physical characteristics of BChS allowed dural closure without cerebrospinal fluid (CSF) leak. There were no differences in fluid leakage pressures between the BChS, dura, and CM groups. Histologic analysis showed fibroblast migration with adequate dural regeneration. CONCLUSIONS: BChS is an ideal alternative for a watertight dural closure because it can be sutured, and it induces organized regeneration with fibroblasts without evidence of fibrosis.
José Humberto Sandoval-Sánchez; Rodrigo Ramos-Zúñiga; Sonia Luquín de Anda; Fernando Dellamary; Rocío Gonzalez-Castañeda; Juan De la Cruz Ramírez-Jaimes; Guadalupe Jorge-Espinoza
Related Documents :
2645915 - Antihypertensive effect of insulin reduction in diabetic-hypertensive patients.
4010845 - Low-pressure receptor activity and exaggerated natriuresis in essential hypertension.
1702945 - Long-term effect of cromolyn sodium on nonspecific bronchial hyperresponsiveness: a rev...
2810325 - The intersalt study: background, methods and main results. intersalt co-operative resea...
20545835 - Randomised controlled trial of auto-adjusting positive airway pressure in morbidly obes...
17019185 - Capillary pressure-induced lung injury: fact or fiction?
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-7
Journal Detail:
Title:  World neurosurgery     Volume:  -     ISSN:  1878-8750     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528275     Medline TA:  World Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Neurosurgery, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Surgical Treatment of Dural Arteriovenous Fistulas of the Petrous Apex.
Next Document:  Salvage C2 Ganglionectomy After C2 Nerve Root Decompression Provides Similar Pain Relief as a Single...