Document Detail


A new arteriovenous fistula model to study the development of neointimal hyperplasia.
MedLine Citation:
PMID:  22249138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study describes an alternative arteriovenous fistula (AVF) model in the rat in which the animals develop significant neointimal hyperplasia (NIH) not only at the distal anastomotic site, but also throughout the fistula body. This aortocaval fistula was established by anastomosing the distal end of the renal vein to the abdominal aorta after unilateral nephrectomy. The increased hemodynamic stress resulting from exposing the renal vein to the arterial circulation induced venous NIH as early as 7 days after surgery. This experimental AVF was characterized by the early lack of endothelium, the accumulation of proliferating vascular smooth muscle cells and the neovascularization of the fistula adventitia. In summary, we have described an informative animal model to study the pathobiology of NIH in native AVF.
Authors:
Eddie Manning; Nikolaos Skartsis; Armando M Orta; Omaida C Velazquez; Zhao-Jun Liu; Arif Asif; Loay H Salman; Roberto I Vazquez-Padron
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-13
Journal Detail:
Title:  Journal of vascular research     Volume:  49     ISSN:  1423-0135     ISO Abbreviation:  J. Vasc. Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-04     Completed Date:  2012-06-04     Revised Date:  2014-04-17    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  123-31     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Abdominal / surgery
Arteriovenous Fistula / pathology*
Arteriovenous Shunt, Surgical / methods*
Disease Models, Animal
Hyperplasia / etiology
Male
Neointima / pathology*
Rats
Rats, Sprague-Dawley
Renal Veins / surgery
Grant Support
ID/Acronym/Agency:
1K01HL096413-01/HL/NHLBI NIH HHS; K01 HL096413/HL/NHLBI NIH HHS; R01 DK098511/DK/NIDDK NIH HHS
Comments/Corrections

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