| A New Arteriovenous Fistula Model to Study the Development of Neointimal Hyperplasia. | |
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MedLine Citation:
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PMID: 22249138 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study describes an alternative arteriovenous fistula (AVF) model in the rat in which the animals develop significant neointimal hyperplasia (NIH) not only at the distal anastomotic site, but also throughout the fistula body. This aortocaval fistula was established by anastomosing the distal end of the renal vein to the abdominal aorta after unilateral nephrectomy. The increased hemodynamic stress resulting from exposing the renal vein to the arterial circulation induced venous NIH as early as 7 days after surgery. This experimental AVF was characterized by the early lack of endothelium, the accumulation of proliferating vascular smooth muscle cells and the neovascularization of the fistula adventitia. In summary, we have described an informative animal model to study the pathobiology of NIH in native AVF. |
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Authors:
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Eddie Manning; Nikolaos Skartsis; Armando M Orta; Omaida C Velazquez; Zhao-Jun Liu; Arif Asif; Loay H Salman; Roberto I Vazquez-Padron |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
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Title: Journal of vascular research Volume: 49 ISSN: 1423-0135 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206092 Medline TA: J Vasc Res Country: - |
Other Details:
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Languages: ENG Pagination: 123-131 Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Fla., USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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