| New approaches to blockade of the renin-angiotensin-aldosterone system: overview of regulation of the renin-angiotensin-aldosterone system. | |
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MedLine Citation:
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PMID: 20675960 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The critical role played by the renin-angiotensin-aldosterone system (RAAS) in the regulation of blood pressure and body fluid homeostasis has been well recognized. Angiotensin (Ang) II and aldosterone are the most powerful biologically active products of the RAAS, although there are also other bioactive Ang peptides involved in this system, including AngIII, AngIV, and Ang1-7. In addition to their physiological roles, AngII and aldosterone induce inflammation, cell growth, mitogenesis, apoptosis, migration, and differentiation; regulate gene expression of bioactive substances; and activate multiple intracellular signaling pathways, all of which contribute to cardiovascular tissue injury. During the last decade, both clinical and preclinical studies have demonstrated that various pharmacological interventions of the RAAS exert blood pressure-independent cardiovascular-protective effects. In this Forum Minireview entitled "New approaches to blockade of the renin-angiotensin-aldosterone system", we will discuss the impact of RAAS inhibitors on prevention of the development of hypertension and cardiovascular diseases. Before going into details about the insights into RAAS inhibition that each of the four groups will provide, we herein briefly overview our current understanding of regulation of the circulating RAAS. |
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Authors:
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Akira Nishiyama; Shokei Kim-Mitsuyama |
Publication Detail:
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Type: Journal Article; Review Date: 2010-07-27 |
Journal Detail:
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Title: Journal of pharmacological sciences Volume: 113 ISSN: 1347-8648 ISO Abbreviation: J. Pharmacol. Sci. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2010-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101167001 Medline TA: J Pharmacol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 289-91 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Medicine, Kagawa University, Japan. akira@kms.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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pharmacology Angiotensin II / pharmacology Humans Receptor, Angiotensin, Type 1 / metabolism Renin-Angiotensin System / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Angiotensin, Type 1; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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