Document Detail


New Antiobesity Agents: Lorcaserin (Belviq) and Phentermine/Topiramate ER (Qsymia).
MedLine Citation:
PMID:  24304809     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Obesity is a risk factor for a wide range of conditions, including cardiovascular disease. Although lifestyle modifications remain the cornerstone for the management of obesity, pharmacologic agents may be a helpful addition to patients who have comorbidities and do not respond adequately to diet and exercise. Lorcaserin and phentermine/topiramate ER are 2 long-awaited agents, approved in 2012 for obesity management, 13 years since orlistat received US Food and Drug Administration approval in 1999. Lorcaserin is a serotonin agonist, whereas phentermine/topiramate is a combination of a sympathomimetic agent and an antiepileptic drug; both these agents have been shown to reduce weight significantly and improve cardiovascular and metabolic parameters, such as blood pressure, lipids, and HbA1C. This article reviews the pharmacology and clinical efficacy and safety of each of these agents. The differences among the three available agents for long-term management of obesity will also be examined.
Authors:
Grace Shyh; Angela Cheng-Lai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology in review     Volume:  22     ISSN:  1538-4683     ISO Abbreviation:  Cardiol Rev     Publication Date:    2014 Jan-Feb
Date Detail:
Created Date:  2013-12-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-50     Citation Subset:  IM    
Affiliation:
From the *Department of Pharmacy, Kingsbrook Jewish Medical Center, Brooklyn, NY; and †Montefiore Medical Center, Bronx, NY.
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