Document Detail


New Adamantane Derivatives with Sigma Affinity and Antiproliferative Activity.
MedLine Citation:
PMID:  22530894     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The synthesis of 4-(1-adamantyl)-4,4-diarylbutylamines 1, 5-(1-adamantyl)-5,5-diarylpentylamines 2 and 6-(1-adamantyl)-6,6-diarylhexylamines 3 is described and the σ1, σ2-receptors and sodium channels binding affinity of compounds 1 were investigated. The in vitro activity of compounds 1, 2 and 3 against main cancer cell lines is significant. One of the most active analogs, 1a, had an interesting in vivo anticancer profile against the ovarian cancer cell line IGROV-1, which was associated with an anagelsic activity against the neuropathic pain induced by the main anticancer drugs.
Authors:
Stefanos Riganas; Ioannis Papanastasiou; George B Foscolos; Andrew Tsotinis; Kostas Dimas; Vassilios N Kourafalos; Andreas Eleutheriades; Vassilios I Moutsos; Humaira Khan; Prassa Margarita; Stavroula Georgakopoulou; Angeliki Zaniou; Maria Theodoropoulou; Athanasios Mantelas; Stavroula Pondiki; Alexandre Vamvakides
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-24
Journal Detail:
Title:  Medicinal chemistry (Shariqah (United Arab Emirates))     Volume:  -     ISSN:  1875-6638     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101240303     Medline TA:  Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece. gfosc@pharm.uoa.gr.
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