| Nevoid basal cell carcinoma syndrome: molecular biology and new hypotheses. | |
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MedLine Citation:
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PMID: 10355946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To understand the molecular biology of the nevoid basal cell carcinoma syndrome, the hedgehog signaling network is explained. The syndrome is caused by mutations in patched, a tumor suppressor gene. A single point mutation in one patched allele may be responsible for the malformations found in the syndrome. Inactivation of both patched alleles results in the formation of tumors and cysts (basal cell carcinomas, odontogenic keratocysts, and medulloblastomas). Several new hypotheses are proposed to account for a minority of nevoid basal cell carcinoma syndrome patients. Evidence is provided to suggest that these hypotheses deserve to be investigated. |
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Authors:
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M M Cohen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of oral and maxillofacial surgery Volume: 28 ISSN: 0901-5027 ISO Abbreviation: Int J Oral Maxillofac Surg Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-06-24 Completed Date: 1999-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8605826 Medline TA: Int J Oral Maxillofac Surg Country: DENMARK |
Other Details:
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Languages: eng Pagination: 216-23 Citation Subset: D; IM |
Affiliation:
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Department of Oral & Maxillofacial Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basal Cell Nevus Syndrome / genetics* Body Patterning / genetics Embryonic Induction / genetics Gene Expression Regulation, Developmental Gene Expression Regulation, Neoplastic* Genes, Tumor Suppressor / genetics Hedgehog Proteins Humans Loss of Heterozygosity Membrane Proteins / genetics, physiology Oncogene Proteins / genetics, physiology Point Mutation Proteins / genetics, physiology Receptors, Cell Surface / genetics, physiology Receptors, G-Protein-Coupled* Signal Transduction / genetics Trans-Activators* Transcription Factors / genetics, physiology |
| Chemical | |
Reg. No./Substance:
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0/Gli protein; 0/Hedgehog Proteins; 0/Membrane Proteins; 0/Oncogene Proteins; 0/Proteins; 0/Receptors, Cell Surface; 0/Receptors, G-Protein-Coupled; 0/SMO protein, human; 0/Trans-Activators; 0/Transcription Factors; 0/patched receptors |
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