Document Detail


Nevirapine inhibits the anti-HIV activity of CD8+ cells.
MedLine Citation:
PMID:  23392464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antiretroviral therapy (ART) significantly reduced the CD8 cell noncytotoxic anti-HIV response in 12 HIV-1-infected subjects (P < 0.0001). In separate experiments, CD8(+) cells from long-term survivors were cocultured with HIV-infected CD4(+) cells using varying concentrations of anti-HIV drugs. The antiviral function of CD8(+) cells from 4 of the 14 LTSs was reduced with exposure to 10 μM of nevirapine (P < 0.05). The antiviral activity of CD8(+) cells from 2 LTSs was inhibited by 5 μM of zidovudine. These studies indicate that nevirapine and probably zidovudine can inhibit the anti-HIV activity of CD8(+) cells and thus could influence the effectiveness of antiretroviral therapy.
Authors:
Lianxing Liu; Lin Wang; Liusheng Huang; Vincent Siu; Fernando Teque; Francesca T Aweeka; Jay A Levy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  63     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-13     Completed Date:  2013-07-08     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  184-8     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Anti-HIV Agents / pharmacology*
CD4-Positive T-Lymphocytes / drug effects*,  immunology
CD8-Positive T-Lymphocytes / drug effects*,  immunology*
Cells, Cultured
Coculture Techniques
HIV Infections / drug therapy,  immunology*
HIV Seropositivity / drug therapy
HIV-1 / drug effects*,  immunology
Humans
Nevirapine / pharmacology
RNA, Viral / blood
Zidovudine / pharmacology
Grant Support
ID/Acronym/Agency:
AI-056992/AI/NIAID NIH HHS; R01 AI056992/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/RNA, Viral; 4B9XT59T7S/Zidovudine; 99DK7FVK1H/Nevirapine
Comments/Corrections

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