Document Detail

Nevi and melanoma: lessons from Turner's syndrome.
MedLine Citation:
PMID:  11244219     Owner:  NLM     Status:  MEDLINE    
Females with Turner's syndrome (TS) have a markedly increased number of cutaneous nevi. While this is a well-recognized risk factor for cutaneous melanoma (CM), the incidence of this tumor in TS and the implications for our understanding of nevi and melanoma have not previously been considered. Here we report a case of an anorectal melanoma in a woman with TS and a review of the literature. Overall, there appears to be a lower than expected incidence of CM. Possible explanations are discussed and in particular the possible relationship between sex hormones and melanoma development as these girls fail to undergo normal pubertal development. Further study of this syndrome may provide important insights into the genetic factors involved in normal melanocyte and nevus development, the potential influence of sex hormones on melanoma development and the relationship between the presence of nevi and the risk of developing CM.
P Gibbs; B M Brady; R Gonzalez; W A Robinson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  202     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-13     Completed Date:  2001-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1-3     Citation Subset:  IM    
University of Colorado Health Sciences Center, Denver, USA.
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MeSH Terms
Melanoma / complications*,  pathology
Nevus / complications*,  pathology
Skin Neoplasms / complications*,  pathology
Turner Syndrome / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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