Document Detail


Neutrophils movement in vitro.
MedLine Citation:
PMID:  12496009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ineffectiveness of the motility of neutrophils is observed in some immunodeficiency disorders. There is a need to find an adequate description and means to evaluate the activity of neutrophils. Early studies describe an individual cell behavior by the cell motility index vector with three components: penetration, directionality, and expansivenesses. Movement quantification has been improved by extending the description of cell activity to two stages of classification. In the first stage, one minute of each cell's behavior is classified into one of five types of cell behavior, using the k-NN method. In the second stage, the sample level that corresponds to the final classification, the Shapiro-Francio test has been used. The proposed new method allows us to describe differences between a normal child and a Chediak-Higashi syndrome patient.
Authors:
Anna Korzyńska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  972     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-12-23     Completed Date:  2003-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
Affiliation:
Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland. akorz@ibib.waw.pl
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MeSH Terms
Descriptor/Qualifier:
Chemotaxis, Leukocyte*
Humans
Microscopy / methods
Models, Biological
Neutrophils / cytology,  physiology*

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