| Neutrophils, but not lymphocytes or monocytes, infiltrate maternal systemic vasculature in women with preeclampsia. | |
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MedLine Citation:
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PMID: 19003640 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Leukocytes are activated in women with preeclampsia, but the class of leukocytes that infiltrates the maternal vasculature and, therefore, is most likely to cause vascular dysfunction is not known. METHODS: Subcutaneous fat biopsies were obtained at Cesarean section or abdominal surgery from 7 normal non-pregnant women, 7 women with normal pregnancies, and 7 women with preeclampsia. Tissues were immunohistochemically stained for CD14, a monocyte/macrophage antigen, CD99, a lymphocyte antigen, and CD66b, a neutrophil antigen. RESULTS: CD14 stained cells were found infiltrated into fat tissue but were not present in vessels for any of the groups. CD99-stained cells were present in approximately 20% to 30% of vessels with no difference among groups. CD66b-stained cells were present in all groups with a significantly greater percentage of vessels stained for preeclamptic than normal pregnant or normal non-pregnant women (70 +/- 6 vs. 43 +/- 9 vs. 21 +/- 5%, respectively, p < 0.01). CD66b cells were the most abundant cell type that infiltrated vessels of preeclamptic women. CONCLUSIONS: 1) A significantly greater number of neutrophils adhered to endothelium and infiltrated into the intimal space in the maternal systemic vasculature of preeclamptic women than in that of normal pregnant women or normal non-pregnant women; 2) No significant difference in lymphocyte infiltration was observed among the patient groups, and lymphocytes were present in much lower numbers than-neutrophils; 3) Monocytes/macrophages were found in fat tissue but not in vessels. We speculate that neutrophils are the class of leukocytes that cause the majority of vascular cell dysfunction in women with preeclampsia. |
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Authors:
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Kristen A Cadden; Scott W Walsh |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 27 ISSN: 1525-6065 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2008 |
Date Detail:
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Created Date: 2008-11-12 Completed Date: 2009-02-17 Revised Date: 2011-11-11 |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: United States |
Other Details:
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Languages: eng Pagination: 396-405 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298-0034, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD / analysis Antigens, CD14 / analysis Case-Control Studies Cell Adhesion Molecules / analysis Endothelium, Vascular / immunology* Female GPI-Linked Proteins Humans Neutrophil Infiltration* Pre-Eclampsia / immunology* Pregnancy Subcutaneous Fat, Abdominal / blood supply, immunology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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HL069851/HL/NHLBI NIH HHS; R01 HL069851-03/HL/NHLBI NIH HHS; R01 HL069851-04/HL/NHLBI NIH HHS; R01 HL069851-05/HL/NHLBI NIH HHS; R01 HL069851-07/HL/NHLBI NIH HHS; R01 HL069851-08/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD14; 0/CD99 protein, human; 0/CEACAM8 protein, human; 0/Cell Adhesion Molecules; 0/GPI-Linked Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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