Document Detail

Neutrophilic spongiosis in pemphigus herpetiformis.
MedLine Citation:
PMID:  8793663     Owner:  NLM     Status:  MEDLINE    
Pemphigus herpetiformis is a rare pemphigus variant with light microscopic features that have historically been described as either "acantholytic dermatitis herpetiformis" or as "eosinophilic spongiosis in pemphigus". The clinical features of this form of pemphigus are reminiscent of dermatitis herpetiformis; however, the direct immunofluorescence finding of epidermal inter-cellular IgG deposition is that of the pemphigus group. We report two patients with clinical presentations suggestive of dermatitis herpetiformis in whom the histopathologic features were those of a neutrophilic intraepidermal blistering disorder. Biopsies showed marked epidermal spongiosis with midepidermal acantholytic vesicles containing predominantly neutrophils and a few eosinophils. Direct immunofluorescence was positive for epidermal intercellular IgG; IgA deposition was not present. Neutrophilic spongiosis, in the absence of a prominent eosinophilic infiltrate, should be recognized as an early finding in some cases of pemphigus, and immunofluorescence studies are justified when this histologic feature is encountered in a skin biopsy.
K M Huhn; V A Tron; N Nguyen; M J Trotter
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  23     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-11-19     Completed Date:  1996-11-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  264-9     Citation Subset:  IM    
Department of Pathology, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Acantholysis / pathology*
Dermatitis Herpetiformis / pathology*
Neutrophils / pathology*
Pemphigus / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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