Document Detail


Neutrophilic inflammation as a major determinant in the progression of cystic fibrosis.
MedLine Citation:
PMID:  17299603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cystic fibrosis (CF) is the most frequent recessive disease in Caucasians. While CF affects all exocrine organs throughout the body, its lung manifestation represents the main cause of morbidity and mortality. Key studies have demonstrated that neutrophilic inflammation occurs early in the course of CF lung disease and that neutrophil-derived factors, most notably elastase, play a crucial pathological role. However, the exact mechanism of neutrophilic inflammation remains unclear. Are there distinct inflammatory phases in the multidecade-long course of CF lung disease? Are CF neutrophils intrinsically abnormal or conditioned by neighboring cells? What is the role of live versus post-apoptotic lung neutrophils? These are some of the questions that this review addresses. This review also argues that the current paradigm that views neutrophils as short-lived indiscriminate killers is seriously flawed. Thus, researchers and clinicians need to view the pathophysiological importance of neutrophils in a new light, to the ultimate benefit of patients.
Authors:
Rabindra Tirouvanziam
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drug news & perspectives     Volume:  19     ISSN:  0214-0934     ISO Abbreviation:  Drug News Perspect.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-02-14     Completed Date:  2007-04-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8809164     Medline TA:  Drug News Perspect     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  609-14     Citation Subset:  IM    
Affiliation:
Herzenberg Laboratory, Department of Genetics, Stanford University, Stanford, California 94305, USA. tirouvan@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology,  therapeutic use
Chronic Disease
Cystic Fibrosis / drug therapy,  genetics,  immunology*,  microbiology
Cystic Fibrosis Transmembrane Conductance Regulator / genetics
Disease Progression
Genotype
Humans
Neutrophil Infiltration* / drug effects
Neutrophils / immunology*
Phenotype
Pneumonia / drug therapy,  genetics,  immunology*,  microbiology
Stress, Physiological / physiopathology
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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