Document Detail


Neutrophil superoxide release and interleukin 8 in acute myocardial infarction: distinction between complicated and uncomplicated states.
MedLine Citation:
PMID:  9179547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Superoxide release in neutrophils and sera levels of interleukin 8 (IL-8) were determined in 15 patients with complicated acute myocardial infarction (MI) and 15 patients with uncomplicated MI. All patients showed increased superoxide release in unstimulated and stimulated neutrophils compared with healthy control subjects, indicating priming of these cells. Superoxide release of unstimulated or stimulated neutrophils was found to be significantly higher in patients with complicated MI than in patients with uncomplicated MI. Thrombolytic therapy did not affect the rates of superoxide release. The neutrophil chemoattractant/activator IL-8 was detected in the sera of all patients, with significantly higher levels in those with complicated MI. The highest levels of IL-8 were detected at admission to the Coronary Care Unit and significantly decreased thereafter, suggesting its contribution to neutrophil-mediated tissue injury. The high levels of IL-8 may be one of the major contributors to the priming of neutrophils in these patients.
Authors:
K Riesenberg; R Levy; A Katz; S Galkop; F Schlaeffer
Related Documents :
23850877 - Effect of gender and itpa polymorphisms on ribavirin-induced anemia in chronic hepatiti...
23040427 - Somatosensory amplification in schizophrenia is associated with preserved neuropsycholo...
23591387 - Cystatin c in assessment of glomerular filtration rate in children and young adults suf...
24013617 - Evaluation of left ventricular diastolic function in nonhypertensive nondiabetic hemodi...
2240917 - Cardiovascular effects of the somatostatin analog octreotide in acromegaly.
3389947 - The association of central retinal artery occlusion and extracranial carotid artery dis...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  27     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-07-24     Completed Date:  1997-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  398-404     Citation Subset:  IM    
Affiliation:
Infectious Disease Laboratory, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Female
Humans
Interleukin-8 / blood*
Male
Middle Aged
Myocardial Infarction / blood*
N-Formylmethionine Leucyl-Phenylalanine / pharmacology
Neutrophils / metabolism*
Ozone / pharmacology
Streptokinase / pharmacology
Superoxides / blood*
Tetradecanoylphorbol Acetate / pharmacology
Chemical
Reg. No./Substance:
0/Interleukin-8; 10028-15-6/Ozone; 11062-77-4/Superoxides; 16561-29-8/Tetradecanoylphorbol Acetate; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Carbonic anhydrase II in the cerebrospinal fluid: its value as a disease marker.
Next Document:  Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid...