Document Detail

Neutrophil superoxide release and interleukin 8 in acute myocardial infarction: distinction between complicated and uncomplicated states.
MedLine Citation:
PMID:  9179547     Owner:  NLM     Status:  MEDLINE    
Superoxide release in neutrophils and sera levels of interleukin 8 (IL-8) were determined in 15 patients with complicated acute myocardial infarction (MI) and 15 patients with uncomplicated MI. All patients showed increased superoxide release in unstimulated and stimulated neutrophils compared with healthy control subjects, indicating priming of these cells. Superoxide release of unstimulated or stimulated neutrophils was found to be significantly higher in patients with complicated MI than in patients with uncomplicated MI. Thrombolytic therapy did not affect the rates of superoxide release. The neutrophil chemoattractant/activator IL-8 was detected in the sera of all patients, with significantly higher levels in those with complicated MI. The highest levels of IL-8 were detected at admission to the Coronary Care Unit and significantly decreased thereafter, suggesting its contribution to neutrophil-mediated tissue injury. The high levels of IL-8 may be one of the major contributors to the priming of neutrophils in these patients.
K Riesenberg; R Levy; A Katz; S Galkop; F Schlaeffer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  27     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-07-24     Completed Date:  1997-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  398-404     Citation Subset:  IM    
Infectious Disease Laboratory, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
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MeSH Terms
Aged, 80 and over
Interleukin-8 / blood*
Middle Aged
Myocardial Infarction / blood*
N-Formylmethionine Leucyl-Phenylalanine / pharmacology
Neutrophils / metabolism*
Ozone / pharmacology
Streptokinase / pharmacology
Superoxides / blood*
Tetradecanoylphorbol Acetate / pharmacology
Reg. No./Substance:
0/Interleukin-8; 10028-15-6/Ozone; 11062-77-4/Superoxides; 16561-29-8/Tetradecanoylphorbol Acetate; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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