Document Detail


Neutrophil and small intestinal lymphocyte migration after Salmonella typhimurium infection: impact of fermentable fiber.
MedLine Citation:
PMID:  15187785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Formula-fed infants have more episodes of acute diarrhea and intestinal infection than do breast-fed infants. Nutrient additions to infant formula that could confer some of the immune benefits of breast milk to formula-fed infants are currently under investigation. This study examined the impact of enteral formulas supplemented with fermentable substrates on small intestinal lymphocyte and neutrophil migration in piglets infected with Salmonella typhimurium. Small intestinal proinflammatory cytokine messenger RNA abundance and in vitro lipopolysaccharide-stimulated interleukin-6 release in whole blood were assessed. METHODS: Piglets were randomized to receive sow milk replacer formula supplemented with methylcellulose (control), soy polysaccharides (SPS) or fructooligosaccharides (FOS). On day 7, half of the piglets were infected with S. typhimurium. Intestinal lymphocyte, neutrophil and whole blood samples were obtained on day 14. RESULTS: After infection, there was decreased lymphocyte migration in the control group but not in the SPS and FOS groups. The SPS group had greater neutrophil migration compared with the control and FOS groups, regardless of infection. Small intestinal abundance of proinflammatory cytokine messenger RNA was not significantly changed by either infection or diet. Blood from the FOS group challenged with lipopolysaccharide for 2 hours exhibited decreased interleukin-6 production compared with blood from the control and SPS groups, regardless of infection. CONCLUSIONS: Supplementation of enteral formulas with SPS maintains the migratory function of small intestinal lymphocytes while increasing that of neutrophils.
Authors:
Laura A Milo; Nancy J Correa-Matos; Sharon M Donovan; Kelly A Tappenden
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  39     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-09     Completed Date:  2005-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-9     Citation Subset:  IM    
Affiliation:
Division of Nutritional Sciences, University of Illinois, Urbana, Illinois, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement / drug effects*
Cytokines / genetics,  metabolism
Dietary Fiber / metabolism,  pharmacology*
Fermentation
Ileum / metabolism
Intestine, Small / cytology,  immunology
Jejunum / metabolism
Lipopolysaccharides / toxicity
Lymphocyte Activation
Lymphocytes / drug effects,  physiology*
Neutrophils / drug effects,  physiology*
Oligosaccharides / pharmacology
Polysaccharides / pharmacology
RNA, Messenger / metabolism
Random Allocation
Salmonella Infections, Animal / immunology*,  microbiology
Salmonella typhimurium*
Swine
Chemical
Reg. No./Substance:
0/Cytokines; 0/Idolax; 0/Lipopolysaccharides; 0/Oligosaccharides; 0/Polysaccharides; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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