| Neutrophil regeneration precedes healing of tissue destruction, as indicated by serum C-reactive protein, in children with cancer recovering from neutropenic fever. | |
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MedLine Citation:
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PMID: 12222715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the relationship between absolute neutrophil count and C-reactive protein (CRP) in the recovery phase of neutropenic fever among paediatric patients with cancer. METHODS: A total of 102 paediatric oncology patients with 177 episodes of fever and neutropenia was studied prospectively in a two-centre setting. Antimicrobial therapy was discontinued 9 d (mean) post-initiation with a mean absolute neutrophil count of 1.8 x 10(9) l(-1) and CRP of 32 mg l(-1). RESULTS: The mean level of CRP below 20 mg l(-1) was reached on day 12. The level of CRP peaked on the day following the commencement of antimicrobial therapy. Throughout the episodes of fever and neutropenia higher levels of CRP were associated with a lower absolute neutrophil count. Following defervescence the pace of marrow recovery as evidenced by an increasing absolute neutrophil count to > 0.2 and > 0.5 x 10(9) l(-1) was more rapid than the normalization of serum CRP. There was a 2-3 d lag period between absolute neutrophil count exceeding the level of 200 x 10(6) l(-1) and the return of CRP to a baseline level. All episodes were treated successfully and there were no fatalities. CONCLUSION: Among patients recovering from neutropenia and fever the signs of marrow recovery remain the key criterion in evaluating the safety of discontinuing antimicrobial therapy, with serum CRP remaining more of an indicator of ongoing tissue repair. |
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Authors:
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K Vettenranta; L Hovi; A Mäkipernaa; H Jalanko; U M Saarinen-Pihkala |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 91 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-09-11 Completed Date: 2003-01-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 915-9 Citation Subset: IM |
Affiliation:
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Hospital for Children and Adolescents, University of Helsinki, Finland. kim.vettenranta@hus.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antineoplastic Agents / adverse effects C-Reactive Protein / analysis* Child Child, Preschool Female Fever / blood*, chemically induced, immunology* Humans Infant Leukocyte Count Male Neoplasms / drug therapy, immunology* Neutropenia / blood*, chemically induced, immunology* Neutrophils / immunology* Predictive Value of Tests Prospective Studies Regeneration / immunology* Wound Healing / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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