| Neutrophil and monocyte activation in chronic kidney disease patients under hemodialysis and its relationship with resistance to recombinant human erythropoietin and to the hemodialysis procedure. | |
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MedLine Citation:
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PMID: 20649681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present work was to further clarify leukocyte activation due to hemodialysis (HD) procedures and to investigate its relationship with recombinant human erythropoietin resistance. Therefore, we studied the expression of CXCR1 and CD11b on neutrophils, as well as the monocyte expression of CD11b, HLA-DR, and CD14. We studied 34 chronic kidney disease (CKD) patients under HD and recombinant human erythropoietin treatment (26 responders and 8 nonresponders to recombinant human erythropoietin therapy). All CKD patients' blood samples were collected before and immediately after the HD procedure. Eighteen healthy individuals (blood donors) were also studied as a control group. Hematological data, neutrophil (CD11b and CXCR1), and monocyte (CD11b, HLA-DR, and CD14) cell surface markers were measured in all patients (before and after the HD procedure) and controls. When compared with the controls, CKD patients presented a significant decrease in CXCR1 neutrophil expression, and in CD14 monocyte expression, accompanied by a significant increase in HLA-DR monocyte expression. When comparing the 2 groups of patients, we found that nonresponders showed an additional decrease in CXCR1 neutrophil expression. After the HD procedure, a statistically significant increase in CD14 and CD11b monocyte surface markers and a decrease in CXCR1 neutrophil expression and in HLA-DR monocyte expression was found. These data further strengthen our previous studies, showing that neutrophils and monocytes are activated in CKD patients, particularly in nonresponder patients. Moreover, this activation is due, at least in part, to the HD procedure, although we should not exclude that it can also be due to the enhanced inflammatory process observed in nonresponder patients. |
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Authors:
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Rui Pereira; Elísio Costa; Marta Gonçalves; Vasco Miranda; Maria do Sameiro Faria; Alexandre Quintanilha; Luís Belo; Margarida Lima; Alice Santos-Silva |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hemodialysis international. International Symposium on Home Hemodialysis Volume: 14 ISSN: 1542-4758 ISO Abbreviation: Hemodial Int Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093910 Medline TA: Hemodial Int Country: Canada |
Other Details:
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Languages: eng Pagination: 295-301 Citation Subset: IM |
Affiliation:
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Biochemistry Department, Faculty of Pharmacy, University of Porto, Porto, Portugal. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anemia / blood, drug therapy, immunology Antigens, CD11b / blood Antigens, CD14 / blood Case-Control Studies Cross-Sectional Studies Drug Resistance / immunology Erythropoietin, Recombinant / pharmacology* Female Humans Kidney Failure, Chronic / blood, drug therapy, immunology*, therapy* Male Middle Aged Monocytes / immunology* Neutrophils / immunology* Receptors, Interleukin-8A / blood Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD11b; 0/Antigens, CD14; 0/Erythropoietin, Recombinant; 0/ITGAM protein, human; 0/Receptors, Interleukin-8A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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