Document Detail


Neutrophil gelatinase-associated lipocalin: a promising biomarker for detecting cardiac surgery-associated acute kidney injury.
MedLine Citation:
PMID:  20412947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute kidney injury is a common and significant problem that occurs in a wide variety of clinical settings. Cardiac surgery-associated acute kidney injury continues to be a well-recognized complication of cardiac surgery with associated morbidity and mortality. A lack of early biomarkers for acute kidney injury has prevented timely interventions to mitigate the effects of acute kidney injury. Because serum creatinine is not a timely marker of acute kidney injury, it cannot be used to institute potentially effective therapies to treat acute kidney injury in patients during phases when the injury is still potentially reversible. Neutrophil gelatinase-associated lipocalin has been identified as a promising biomarker for early detection of acute kidney injury. Several studies have shown that neutrophil gelatinase-associated lipocalin levels increase significantly in patients with acute kidney injury 24 to 48 hours before an increase in serum creatinine is detectable. Recent studies suggest that measurements of neutrophil gelatinase-associated lipocalin levels in patients at risk for cardiac surgery-associated acute kidney injury can facilitate its early diagnosis and allow clinicians to implement therapeutic adjustments that have the potential to reverse renal cellular damage and minimize further kidney injury.
Authors:
Dinna N Cruz; Claudio Ronco; Nevin Katz
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Publication Detail:
Type:  Editorial; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  139     ISSN:  1097-685X     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1101-6     Citation Subset:  AIM; IM    
Copyright Information:
2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
Affiliation:
Department of Nephrology Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Acute-Phase Proteins / metabolism*
Biological Markers / metabolism
Cardiac Surgical Procedures / adverse effects*
Creatinine / metabolism
Cystatin C / metabolism
Early Diagnosis
Humans
Interleukin-18 / metabolism
Kidney Diseases / diagnosis*,  etiology,  metabolism
Lipocalins / metabolism*
Membrane Glycoproteins / metabolism
Predictive Value of Tests
Prognosis
Proto-Oncogene Proteins / metabolism*
Receptors, Virus / metabolism
Time Factors
Up-Regulation
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Biological Markers; 0/CST3 protein, human; 0/Cystatin C; 0/HAVCR1 protein, human; 0/Interleukin-18; 0/LCN2 protein, human; 0/Lipocalins; 0/Membrane Glycoproteins; 0/Proto-Oncogene Proteins; 0/Receptors, Virus; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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