Document Detail


Neutrophil gelatinase-associated lipocalin in peritoneal effluent: evaluation in peritoneal dialysis patients in basal condition.
MedLine Citation:
PMID:  23284073     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: In the present study, we assessed expression of neutrophil gelatinase-associated lipocalin (NGAL) in peritoneal effluent (pNGAL) from peritoneal dialysis (PD) patients, and we evaluated factors that might affect its level in basal conditions.
METHODS: Our cross-sectional study included all 69 patients on PD at our institution. We evaluated patient history, hydration status, residual renal function, indices of dialysis adequacy, peritoneal transport type, serum C-reactive protein, ferritin, serum NGAL (sNGAL) and pNGAL. Univariate and multivariate linear regression models were used to evaluate predictors of pNGAL.
RESULTS: Of the study patients, 39 (56.5%) were men, and 54 (78.3%) were on continuous ambulatory PD. Median age in the group was 61 years [interquartile range (IQR): 46.5 - 71 years]. Median sNGAL was 487 ng/mL (IQR: 407 - 586 ng/mL), and median pNGAL was 35 ng/mL (IQR: 21 - 46 ng/mL). dNGAL correlated directly with weekly dialytic clearance of creatinine (ρ = 0.291, p = 0.02) and with sNGAL (ρ = 0.269, p = 0.031). The same variables were also independent predictors of pNGAL (β = 0.30 and 0.29 respectively, both p < 0.05) in multivariate analysis.
CONCLUSIONS: In our analysis, basal levels of pNGAL were influenced by sNGAL and by dialytic clearance of creatinine.
Authors:
Francesca Martino; Ilenia Filippi; Davide Giavarina; Gianpaolo Amici; Massimo de Cal; Manish Kaushik; Maria Pia Rodighiero; Carlo Crepaldi; Claudio Ronco
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Publication Detail:
Type:  Journal Article     Date:  2013-01-02
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  33     ISSN:  1718-4304     ISO Abbreviation:  Perit Dial Int     Publication Date:    2013 Jul-Aug
Date Detail:
Created Date:  2013-07-11     Completed Date:  2014-03-13     Revised Date:  2014-07-01    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  379-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / metabolism*
Aged
C-Reactive Protein / analysis
Cross-Sectional Studies
Female
Ferritins / analysis
Humans
Lipocalins / blood,  metabolism*
Male
Middle Aged
Multivariate Analysis
Peritoneal Dialysis*
Proto-Oncogene Proteins / blood,  metabolism*
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins; 9007-41-4/C-Reactive Protein; 9007-73-2/Ferritins
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