Document Detail

Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury.
MedLine Citation:
PMID:  20397003     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To study the impact of inflammation/sepsis on the concentrations of neutrophil gelatinase-associated lipocalin (NGAL) in plasma and urine in adult intensive care unit (ICU) patients and to estimate the predictive properties of NGAL in plasma and urine for early detection of acute kidney injury (AKI) in patients with septic shock. METHODS: Sixty-five patients admitted to the general ICU at the Karolinska University Hospital Solna, Sweden, with normal plasma creatinine were assessed for eligibility. Twenty-seven patients with systemic inflammatory response syndrome (SIRS), severe sepsis, or septic shock without AKI and 18 patients with septic shock and concomitant AKI were included in the final analysis. Plasma and urine were analyzed twice daily for plasma NGAL (pNGAL), C-reactive protein (CRP), procalcitonin, myeloperoxidase, plasma cystatin C, plasma creatinine, urine NGAL (uNGAL), urine cystatin C, and urine alpha1-microglobulin. RESULTS: Of the 45 patients, 40 had elevated peak levels of pNGAL. Peak levels of pNGAL were not significantly different between septic shock patients with and without AKI. Peak levels of uNGAL were below the upper reference limit in all but four patients without AKI. uNGAL was a good predictor (area under ROC 0.86) whereas pNGAL was a poor predictor (area under ROC 0.67) for AKI within the next 12 h in patients with septic shock. CONCLUSIONS: pNGAL is raised in patients with SIRS, severe sepsis, and septic shock and should be used with caution as a marker of AKI in ICU patients with septic shock. uNGAL is more useful in predicting AKI as the levels are not elevated in septic patients without AKI.
Johan Mårtensson; Max Bell; Anders Oldner; Shengyuan Xu; Per Venge; Claes-Roland Martling
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Publication Detail:
Type:  Journal Article     Date:  2010-04-16
Journal Detail:
Title:  Intensive care medicine     Volume:  36     ISSN:  1432-1238     ISO Abbreviation:  Intensive Care Med     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-09     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1333-40     Citation Subset:  IM    
Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.
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MeSH Terms
Acute-Phase Proteins / metabolism*,  urine
Biological Markers / blood
Critical Illness
Early Diagnosis
Kidney Failure, Acute / diagnosis*,  physiopathology
Lipocalins / blood,  metabolism*,  urine
Middle Aged
Predictive Value of Tests*
Proto-Oncogene Proteins / blood,  metabolism*,  urine
Sensitivity and Specificity
Sepsis / metabolism*
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Biological Markers; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins

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