Document Detail


Neutrophil gelatinase-associated lipocalin (NGAL) reflects iron status in haemodialysis patients.
MedLine Citation:
PMID:  19549696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: An iron deficiency is often present in haemodialysis (HD) patients; however, although transferrin saturation (TSAT) of <20% and/or serum ferritin of <200 ng/mL should express iron scarcity, in HD patients high ferritin levels could be related to inflammation rather than reflecting optimal iron stores. METHODS: The aim of the present study was to evaluate serum levels of neutrophil gelatinase-associated lipocalin (NGAL), a small siderophore-binding protein, in a cohort of 56 chronic HD patients in order to determine its possible relationships with iron status. RESULTS: NGAL levels were markedly higher in HD patients than in healthy controls; furthermore, HD patients with TSAT <20% had lower NGAL values than healthy controls, whereas the correction of iron deficiency by means of chronic i.v. iron administration significantly increased NGAL values from baseline. Findings from univariate and multivariate analyses demonstrated that NGAL was a significant predictor of hsCRP, spKT/V and TSAT. In ROC analysis, a NGAL cut-off level of <or=473 ng/mL had a greater sensitivity and specificity than a ferritin level of <200 ng/mL in identifying iron deficiency among HD patients. CONCLUSIONS: The findings demonstrated that HD patients have altered NGAL values probably because this protein is involved in the maintenance of iron equilibrium. Finally, NGAL might be proposed as a new tool in the assessment of iron deficiency and in the management of iron therapy for HD patients.
Authors:
Davide Bolignano; Giuseppe Coppolino; Adolfo Romeo; Luciano De Paola; Antoine Buemi; Antonio Lacquaniti; Giacomo Nicocia; Luigi Lombardi; Michele Buemi
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Publication Detail:
Type:  Journal Article     Date:  2009-06-23
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  24     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2010-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  3398-403     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Chair of Nephrology, University of Messina, UOC Nefrologia e Dialisi, Catanzaro, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins
Adult
Aged
C-Reactive Protein / analysis
Female
Humans
Iron / metabolism*
Lipocalins / blood*
Male
Middle Aged
Proto-Oncogene Proteins / blood*
ROC Curve
Regression Analysis
Renal Dialysis*
Transferrin / metabolism
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins; 11096-37-0/Transferrin; 7439-89-6/Iron; 9007-41-4/C-Reactive Protein

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