| Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene. | |
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MedLine Citation:
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PMID: 19540040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The small 25 kDa peptide, neutrophil gelatinase-associated lipocalin (NGAL), first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. The aim of the present review is to point out the main contradictory, sometimes even paradoxical, effects attributed to NGAL in human neoplasias. For instance, acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. Moreover, in thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. However, on the contrary, some studies have demonstrated that NGAL can inhibit the pro-neoplastic factor HIF-1alpha, FA-Kinase phosphorylation and also VEGF synthesis, thus suggesting that, in alternative conditions, NGAL also, paradoxically, has an anti-tumoral and anti-metastatic effect in neoplasias of, for example, the colon, ovary and pancreas. Finally, in the field of clinical oncology, attention is currently focused on the potential use of NGAL levels in making an early diagnosis, establishing a prognosis and predicting response to different treatments. |
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Authors:
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Davide Bolignano; Valentina Donato; Antonio Lacquaniti; Maria Rosaria Fazio; Caterina Bono; Giuseppe Coppolino; Michele Buemi |
Publication Detail:
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Type: Journal Article; Review Date: 2009-06-18 |
Journal Detail:
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Title: Cancer letters Volume: 288 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 10-6 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Internal Medicine, University of Messina, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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metabolism* Early Detection of Cancer Humans Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Lipocalins / metabolism* Matrix Metalloproteinase 9 / metabolism NF-kappa B / metabolism Neoplasm Invasiveness Neoplasm Staging Neoplasms / diagnosis, metabolism*, pathology Predictive Value of Tests Prognosis Proto-Oncogene Proteins / metabolism* Signal Transduction Tumor Markers, Biological / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/HIF1A protein, human; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/LCN2 protein, human; 0/Lipocalins; 0/NF-kappa B; 0/Proto-Oncogene Proteins; 0/Tumor Markers, Biological; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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