| Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease. | |
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MedLine Citation:
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PMID: 19176795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Chronic kidney disease (CKD) has recently assumed epidemic proportion, becoming a troubling emerging cause of morbidity, especially if it progresses to terminal stage (ESRD). The authors aimed to evaluate whether neutrophil gelatinase-associated lipocalin (NGAL), a novel specific biomarker of acute kidney injury, could predict the progression of CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Serum and urinary NGAL levels, together with a series of putative progression factors, were evaluated in a cohort of 96 patients (mean age: 57 +/- 16 years) affected by nonterminal CKD (eGFR > or =15 ml/min/1.73 m(2)) of various etiology. Progression of CKD, assessed as doubling of baseline serum creatinine and/or onset of ESRD, was evaluated during follow-up. RESULTS: At baseline, both serum and urinary NGAL were inversely, independently, and closely related to eGFR. After a median follow-up of 18.5 mo (range 1.01 to 20), 31 patients (32%) reached the composite endpoint. At baseline, these patients were significantly older and showed increased serum creatinine, calcium-phosphate product, C-reactive protein, fibrinogen, daily proteinuria, and NGAL levels, whereas eGFR values were significantly lower. Univariate followed by multivariate Cox proportional hazard regression analysis showed that urinary NGAL and sNGAL predicted CKD progression independently of other potential confounders, including eGFR and age. CONCLUSION: In patients with CKD, NGAL closely reflects the entity of renal impairment and represents a strong and independent risk marker for progression of CKD. |
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Authors:
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Davide Bolignano; Antonio Lacquaniti; Giuseppe Coppolino; Valentina Donato; Susanna Campo; Maria Rosaria Fazio; Giacomo Nicocia; Michele Buemi |
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Publication Detail:
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Type: Journal Article Date: 2009-01-28 |
Journal Detail:
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Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 4 ISSN: 1555-905X ISO Abbreviation: Clin J Am Soc Nephrol Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-16 Completed Date: 2009-06-11 Revised Date: 2010-09-23 |
Medline Journal Info:
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Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 337-44 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Messina, Messima, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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urine* Adult Aged Biological Markers / blood, urine Chronic Disease Creatinine / blood Disease Progression Female Glomerular Filtration Rate Humans Kaplan-Meiers Estimate Kidney Diseases / complications, metabolism*, physiopathology Kidney Failure, Chronic / blood, etiology*, physiopathology Lipocalins / blood*, urine* Male Middle Aged Predictive Value of Tests Proportional Hazards Models Prospective Studies Proto-Oncogene Proteins / blood*, urine* ROC Curve Risk Assessment Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Biological Markers; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins; 60-27-5/Creatinine |
| Comments/Corrections | |
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