| Neutrophil function in infection-prone children. | |
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MedLine Citation:
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PMID: 7436443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven variables connected with the function of the neutrophil granulocyte were studied in 24 children who had undue susceptibilities to infections. The phagocytosis rate of IgG-coated latex particles by the patients' neutrophils was significantly reduced compared with an age-matched control group. The chemokinetic effect of patients' sera on normal polymorphonuclear neutrophil leucocytes was reduced too, especially in heated (56 degrees C, 30 min) serum. Spontaneous chemotactic activity in the patients' sera was significantly lower than in sera from healthy adults and from the age-matched control group. A functional index based on the 7 variables of neutrophil function was constructed. The score of the functional index was correlated to the severity of the patients' clinical condition and discriminated well between normal children and those with undue susceptibility to infections. |
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Authors:
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L Håkansson; T Foucard; R Hällgren; P Venge |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of disease in childhood Volume: 55 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 1980 Oct |
Date Detail:
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Created Date: 1981-01-16 Completed Date: 1981-01-16 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 776-81 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Bacterial Infections / blood* Chemotaxis, Leukocyte Child Child, Preschool Female Granulocytes / physiology Humans Immunoglobulin G Infant Male Neutrophils / physiology* Phagocytosis Recurrence |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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