Document Detail


Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice.
MedLine Citation:
PMID:  9344234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the in vivo effects of ONO-5046xNa, a specific neutrophil elastase (NE) inhibitor, on the growth of 2 non-small cell lung cancer cell lines, EBC-1 and PC-3, transplanted into severe combined immunodeficiency (scid) mice. The daily intraperitoneal injection of ONO-5046xNa (50 mg/kg/day) completely suppressed the tumor growth in EBC-1, a human squamous carcinoma cell line which produces immunoreactive NE. By contrast, in PC-3, a human adenocarcinoma cell line which is unable to produce immunoreactive NE, the ONO-5046xNa treatment caused delayed growth of the tumor. These findings suggest that ONO-5046xNa may have a clinical role in preventing the growth of human non-small cell lung cancer.
Authors:
M Inada; J Yamashita; M Ogawa
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Research communications in molecular pathology and pharmacology     Volume:  97     ISSN:  1078-0297     ISO Abbreviation:  Res. Commun. Mol. Pathol. Pharmacol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-11-17     Completed Date:  1997-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9437512     Medline TA:  Res Commun Mol Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-32     Citation Subset:  IM    
Affiliation:
Department of Surgery II, Kumamoto University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy*,  pathology
Animals
Antineoplastic Agents / administration & dosage,  pharmacology*
Carcinoma, Non-Small-Cell Lung / drug therapy*,  pathology
Carcinoma, Squamous Cell / drug therapy*,  pathology
Cell Division / drug effects
Female
Glycine / administration & dosage,  analogs & derivatives*,  pharmacology
Humans
Leukocyte Elastase / antagonists & inhibitors*
Lung Neoplasms / drug therapy*,  pathology
Mice
Mice, SCID
Neutrophils / enzymology
Serine Proteinase Inhibitors / administration & dosage,  pharmacology*
Sulfonamides / administration & dosage,  pharmacology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Serine Proteinase Inhibitors; 0/Sulfonamides; 127373-66-4/ONO 5046; 56-40-6/Glycine; EC 3.4.21.37/Leukocyte Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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