Document Detail

Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.
MedLine Citation:
PMID:  18410258     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Neutrophil elastase (NE) may play a key role in the development of acute lung injury (ALI) or ARDS. NE activity (NEA) was measured in patients with ALI treated with a selective NE inhibitor. METHODS: NEA and NE-alpha1-antitrypsin (NE-AT) complex were measured in plasma before, during and after the administration of the selective NE inhibitor, sivelestat, in 32 patients with a diagnosis of ALI or ARDS. NEA index (NEAI) was calculated as NEA/NE-AT. The sequential organ failure assessment (SOFA) score and the ratio PaO(2)/fraction of inspired oxygen (FiO(2)) were measured. RESULTS: NEA and NE-AT was raised in all patients. Sivelestat reduced NEAI and NEA (P < 0.01 for both) but not NE-AT and NEA, and NEAI returned to pretreatment levels. NEA correlated closely with NE-AT before, but not after treatment. No relationship was observed between these indices and SOFA score or PaO(2)/FiO(2) ratio. CONCLUSIONS: Sivelestat reduced NEA and NEAI in patients with ALI or ARDS suggesting NE inhibition. A larger study is needed to determine the relationship of NEA, NE-AT and NEAI with the outcome of ALI/ARDS.
Satoru Hashimoto; Yoko Okayama; Nobuaki Shime; Akio Kimura; Yosuke Funakoshi; Kazuhito Kawabata; Akitoshi Ishizaka; Fumimasa Amaya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-10
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  13     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-22     Completed Date:  2008-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  581-4     Citation Subset:  IM    
Department of Anaesthesiology and Intensive Care, Kyoto Prefectural School of Medicine, Kyoto, Japan.
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MeSH Terms
Enzyme Inhibitors / therapeutic use
Glycine / analogs & derivatives,  therapeutic use
Leukocyte Elastase / antagonists & inhibitors,  blood*
Middle Aged
Respiratory Distress Syndrome, Adult / enzymology*
Sulfonamides / therapeutic use
alpha 1-Antitrypsin / blood*
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Sulfonamides; 0/alpha 1-Antitrypsin; 0/alpha 1-antitrypsin-leukocyte elastase complex; 127373-66-4/ONO 5046; 56-40-6/Glycine; EC Elastase

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