| Neutrophil elastase activity in acute lung injury and respiratory distress syndrome. | |
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MedLine Citation:
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PMID: 18410258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Neutrophil elastase (NE) may play a key role in the development of acute lung injury (ALI) or ARDS. NE activity (NEA) was measured in patients with ALI treated with a selective NE inhibitor. METHODS: NEA and NE-alpha1-antitrypsin (NE-AT) complex were measured in plasma before, during and after the administration of the selective NE inhibitor, sivelestat, in 32 patients with a diagnosis of ALI or ARDS. NEA index (NEAI) was calculated as NEA/NE-AT. The sequential organ failure assessment (SOFA) score and the ratio PaO(2)/fraction of inspired oxygen (FiO(2)) were measured. RESULTS: NEA and NE-AT was raised in all patients. Sivelestat reduced NEAI and NEA (P < 0.01 for both) but not NE-AT and NEA, and NEAI returned to pretreatment levels. NEA correlated closely with NE-AT before, but not after treatment. No relationship was observed between these indices and SOFA score or PaO(2)/FiO(2) ratio. CONCLUSIONS: Sivelestat reduced NEA and NEAI in patients with ALI or ARDS suggesting NE inhibition. A larger study is needed to determine the relationship of NEA, NE-AT and NEAI with the outcome of ALI/ARDS. |
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Authors:
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Satoru Hashimoto; Yoko Okayama; Nobuaki Shime; Akio Kimura; Yosuke Funakoshi; Kazuhito Kawabata; Akitoshi Ishizaka; Fumimasa Amaya |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-10 |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: 13 ISSN: 1440-1843 ISO Abbreviation: Respirology Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-22 Completed Date: 2008-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: Australia |
Other Details:
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Languages: eng Pagination: 581-4 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Intensive Care, Kyoto Prefectural School of Medicine, Kyoto, Japan. satoru@koto.kpu-m.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Enzyme Inhibitors / therapeutic use Female Glycine / analogs & derivatives, therapeutic use Humans Leukocyte Elastase / antagonists & inhibitors, blood* Male Middle Aged Respiratory Distress Syndrome, Adult / enzymology* Sulfonamides / therapeutic use alpha 1-Antitrypsin / blood* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Sulfonamides; 0/alpha 1-Antitrypsin; 0/alpha 1-antitrypsin-leukocyte elastase complex; 127373-66-4/ONO 5046; 56-40-6/Glycine; EC 3.4.21.37/Leukocyte Elastase |
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