Document Detail


Neutrophil chemotactic activity is increased in nasal secretions of long-distance runners.
MedLine Citation:
PMID:  8775577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For years physicians have observed a high incidence of infections after strenuous exercise. Recent observations suggest an increase of neutrophils in the upper airways following a long-distance race. In order to elucidate mechanisms responsible for the influx of neutrophils in airway mucosa, we tested neutrophil chemotactic activity (NCA) in nasal lavages of amateur runners. Thirty-six amateur runners entered in a marathon race (42.2 km) and 24 healthy sedentary subjects participated in the study. Nasal lavages (NAL) were performed several times before and after the race. The total number of recovered neutrophils was measured and the NCA was determined using a modified Boyden chamber. The number of PMNs in NAL of the runners immediately after the race was increased 2.7-fold (p < 0.01) compared to the values obtained on the same day prior to the race (128 +/- 19 vs. 48 +/- 16, x 10(3)), remained elevated several days after the race and returned to baseline after 1 week. The race resulted also in a 2.5-fold (p < 0.01) increase of NCA immediately after the competition compared to the pre-race values of the same day (78 +/- 5.2 cells/8 High Power Fields, HPF vs. 31 +/- 3.4 cells/8 HPF). The findings suggest that NCA might play an important role in attracting neutrophils to the airways. The nature and origin of NCA in airway secretions is presently not known.
Authors:
G Müns; I Rubinstein; P Singer
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of sports medicine     Volume:  17     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-12-06     Completed Date:  1996-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  56-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chemotaxis, Leukocyte*
Exercise / physiology
Humans
Middle Aged
Nasal Lavage Fluid / cytology*
Neutrophils / physiology
Running / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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