Document Detail

Neutrophil chemotactic activity in milk-induced asthma.
MedLine Citation:
PMID:  6406587     Owner:  NLM     Status:  MEDLINE    
Four subjects with clinical histories of milk-induced asthma were studied (three allergic to cow's milk; one to soya milk). In each instance, skin prick tests, RAST (IgE and IgG4), the basophil histamine release, and serum precipitins, using appropriate milk extracts, were negative. After the ingestion of milk all the subjects developed a reproducible and dose-dependent increase in airflow limitation. Three patients (two allergic to cow's milk; one to soya milk) gave a characteristic immediate-type reaction, which was maximal at 30 min after challenge. The fourth individual developed an isolated late-phase response, with maximal airways obstruction 3 hr after ingesting milk. In the three subjects who gave an early reaction, wheezing was accompanied by an elevation in circulating neutrophil chemotactic activity (NCA). This was not observed in the individual with the isolated late reaction. By Sephacryl S-400 gel-filtration chromatography it was shown that NCA of the early reactions eluted with proteins having an estimated molecular weight of 600,000 daltons. The immediate asthmatic response in peak expiratory flow rate and the elevation in NCA were inhibited by the prior oral administration of either disodium cromoglycate (DSCG) or oral beclomethasone dipropionate (BDP). In contrast, DSCG had no effect on airways obstruction in the subject with the isolated late asthmatic response, although inhibition was achieved by BDP.
N Papageorgiou; T H Lee; T Nagakura; O Cromwell; D G Wraith; A B Kay
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  72     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-07-29     Completed Date:  1983-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-82     Citation Subset:  AIM; IM    
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MeSH Terms
Asthma / complications,  diet therapy,  immunology*
Beclomethasone / therapeutic use
Chemotaxis, Leukocyte*
Cromolyn Sodium / therapeutic use
Food Hypersensitivity / complications*
Middle Aged
Milk / adverse effects
Neutrophils / immunology
Reg. No./Substance:
15826-37-6/Cromolyn Sodium; 4419-39-0/Beclomethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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